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Complete remission of metastatic renal cell carcinoma to the bone with sunitinib

Target agents such as tyrosine kinase inhibitors have improved renal cell carcinoma (RCC) patient outcomes. However, complete remission (CR) with target agents is rare. Furthermore, CR of bone metastasis is much less common. We report a case of CR in bone and lung metastatic RCC. Radical nephrectomy...

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Detalles Bibliográficos
Autores principales: Yoshimura, Akihiro, Nakata, Wataru, Yamamichi, Gaku, Tsujimura, Go, Tsujimoto, Yuichi, Nin, Mikio, Tsujihata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184521/
https://www.ncbi.nlm.nih.gov/pubmed/32368498
http://dx.doi.org/10.1016/j.eucr.2020.101213
Descripción
Sumario:Target agents such as tyrosine kinase inhibitors have improved renal cell carcinoma (RCC) patient outcomes. However, complete remission (CR) with target agents is rare. Furthermore, CR of bone metastasis is much less common. We report a case of CR in bone and lung metastatic RCC. Radical nephrectomy was performed first, and clear cell RCC was diagnosed. Thereafter, sunitinib was started, and bone and lung metastases resolved entirely after 8 months of treatment. Sunitinib therapy was discontinued after 2 years because of the adverse event of proteinuria. However, the patient has remained in CR for over 1 year after sunitinib cessation.