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Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50

Genome instability is the fundamental hallmark of malignant tumors. Tumor suppressors often play a role in maintaining genome stability. Our previous genetic screen identified inositol polyphosphate 4-phosphatase type B (INPP4B), primarily hydrolyzing phosphatidylinositol 3, 4-disphosphate, is a pot...

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Detalles Bibliográficos
Autores principales:	Sun, Yue, Ning, Xuelian, Fan, Jiankun, Hu, Jiandong, Jiang, Yanting, Hu, Ziqi, Paulo, Joao A., Liu, Jichao, Qiu, Xiaohong, Xu, Hui, Fu, Songbin, Gygi, Steven P., Zhang, Jinwei, Zhou, Chunshui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184567/ https://www.ncbi.nlm.nih.gov/pubmed/32341333 http://dx.doi.org/10.1038/s41419-020-2491-3

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