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The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonal...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184733/ https://www.ncbi.nlm.nih.gov/pubmed/32341346 http://dx.doi.org/10.1038/s41467-020-15123-0 |
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| author | Gröschel, Matthias I. Meehan, Conor J. Barilar, Ivan Diricks, Margo Gonzaga, Aitor Steglich, Matthias Conchillo-Solé, Oscar Scherer, Isabell-Christin Mamat, Uwe Luz, Christian F. De Bruyne, Katrien Utpatel, Christian Yero, Daniel Gibert, Isidre Daura, Xavier Kampmeier, Stefanie Rahman, Nurdyana Abdul Kresken, Michael van der Werf, Tjip S. Alio, Ifey Streit, Wolfgang R. Zhou, Kai Schwartz, Thomas Rossen, John W. A. Farhat, Maha R. Schaible, Ulrich E. Nübel, Ulrich Rupp, Jan Steinmann, Joerg Niemann, Stefan Kohl, Thomas A. |
| author_facet | Gröschel, Matthias I. Meehan, Conor J. Barilar, Ivan Diricks, Margo Gonzaga, Aitor Steglich, Matthias Conchillo-Solé, Oscar Scherer, Isabell-Christin Mamat, Uwe Luz, Christian F. De Bruyne, Katrien Utpatel, Christian Yero, Daniel Gibert, Isidre Daura, Xavier Kampmeier, Stefanie Rahman, Nurdyana Abdul Kresken, Michael van der Werf, Tjip S. Alio, Ifey Streit, Wolfgang R. Zhou, Kai Schwartz, Thomas Rossen, John W. A. Farhat, Maha R. Schaible, Ulrich E. Nübel, Ulrich Rupp, Jan Steinmann, Joerg Niemann, Stefan Kohl, Thomas A. |
| author_sort | Gröschel, Matthias I. |
| collection | PubMed |
| description | Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. |
| format | Online Article Text |
| id | pubmed-7184733 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71847332020-04-30 The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia Gröschel, Matthias I. Meehan, Conor J. Barilar, Ivan Diricks, Margo Gonzaga, Aitor Steglich, Matthias Conchillo-Solé, Oscar Scherer, Isabell-Christin Mamat, Uwe Luz, Christian F. De Bruyne, Katrien Utpatel, Christian Yero, Daniel Gibert, Isidre Daura, Xavier Kampmeier, Stefanie Rahman, Nurdyana Abdul Kresken, Michael van der Werf, Tjip S. Alio, Ifey Streit, Wolfgang R. Zhou, Kai Schwartz, Thomas Rossen, John W. A. Farhat, Maha R. Schaible, Ulrich E. Nübel, Ulrich Rupp, Jan Steinmann, Joerg Niemann, Stefan Kohl, Thomas A. Nat Commun Article Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. Nature Publishing Group UK 2020-04-27 /pmc/articles/PMC7184733/ /pubmed/32341346 http://dx.doi.org/10.1038/s41467-020-15123-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Gröschel, Matthias I. Meehan, Conor J. Barilar, Ivan Diricks, Margo Gonzaga, Aitor Steglich, Matthias Conchillo-Solé, Oscar Scherer, Isabell-Christin Mamat, Uwe Luz, Christian F. De Bruyne, Katrien Utpatel, Christian Yero, Daniel Gibert, Isidre Daura, Xavier Kampmeier, Stefanie Rahman, Nurdyana Abdul Kresken, Michael van der Werf, Tjip S. Alio, Ifey Streit, Wolfgang R. Zhou, Kai Schwartz, Thomas Rossen, John W. A. Farhat, Maha R. Schaible, Ulrich E. Nübel, Ulrich Rupp, Jan Steinmann, Joerg Niemann, Stefan Kohl, Thomas A. The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title | The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title_full | The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title_fullStr | The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title_full_unstemmed | The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title_short | The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia |
| title_sort | phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist stenotrophomonas maltophilia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184733/ https://www.ncbi.nlm.nih.gov/pubmed/32341346 http://dx.doi.org/10.1038/s41467-020-15123-0 |
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