Survivors of Ebola Virus Disease Develop Polyfunctional Antibody Responses

Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized....

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Detalles Bibliográficos
Autores principales: Gunn, Bronwyn M, Roy, Vicky, Karim, Marcus M, Hartnett, Jessica N, Suscovich, Todd J, Goba, Augustine, Momoh, Mambu, Sandi, John Demby, Kanneh, Lansana, Andersen, Kristian G, Shaffer, Jeffrey G, Schieffelin, John S, Garry, Robert F, Grant, Donald S, Alter, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184900/
https://www.ncbi.nlm.nih.gov/pubmed/31301137
http://dx.doi.org/10.1093/infdis/jiz364
Descripción
Sumario:Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized. In this study, serum antibodies from Ebola virus disease (EVD) survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions. Antibodies from EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1. In conclusion, development of functional antibodies follows survival of acute EVD.

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