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Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China

While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely infor...

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Autor principal: Leung, Char
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184979/
https://www.ncbi.nlm.nih.gov/pubmed/32353398
http://dx.doi.org/10.1016/j.mad.2020.111255
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author Leung, Char
author_facet Leung, Char
author_sort Leung, Char
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description While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. Based on the data of 154 individuals from 26 provinces, age remained a key mortality risk factor among geriatric patients of different ages. While dyspnoea and chest pain/discomfort were more commonly seen in deceased patients as they represented severe pneumonia, fever was more prominent in surviving patients. This was likely due to the lower baseline body temperature observed in elderly which translated to a lower maximum temperature of fever. However, lowering the threshold temperature for fever is not recommended in surveillance. Instead, baseline body temperature measured on a regular basis should be used to define the threshold temperature for fever. Against mixed results, more research should be done on identifying comorbidities associated with mortality in geriatric patients.
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spelling pubmed-71849792020-04-27 Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China Leung, Char Mech Ageing Dev Article While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. Based on the data of 154 individuals from 26 provinces, age remained a key mortality risk factor among geriatric patients of different ages. While dyspnoea and chest pain/discomfort were more commonly seen in deceased patients as they represented severe pneumonia, fever was more prominent in surviving patients. This was likely due to the lower baseline body temperature observed in elderly which translated to a lower maximum temperature of fever. However, lowering the threshold temperature for fever is not recommended in surveillance. Instead, baseline body temperature measured on a regular basis should be used to define the threshold temperature for fever. Against mixed results, more research should be done on identifying comorbidities associated with mortality in geriatric patients. Elsevier B.V. 2020-06 2020-04-27 /pmc/articles/PMC7184979/ /pubmed/32353398 http://dx.doi.org/10.1016/j.mad.2020.111255 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Leung, Char
Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title_full Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title_fullStr Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title_full_unstemmed Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title_short Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China
title_sort risk factors for predicting mortality in elderly patients with covid-19: a review of clinical data in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184979/
https://www.ncbi.nlm.nih.gov/pubmed/32353398
http://dx.doi.org/10.1016/j.mad.2020.111255
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