NO up-regulates migraine-related CGRP via activation of an Akt/GSK-3β/NF-κB signaling cascade in trigeminal ganglion neurons

The release of the neuropeptide CGRP from the trigeminal ganglion neurons (TGNs) plays a central role in migraine. Whereas CGRP can activate NO release from ganglionic glial cells, NO in turn enhances CGRP release. However, it remains unclear how NO promotes CGRP release. Here, we report that the NO...

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Detalles Bibliográficos
Autores principales: Yao, Gang, Man, Yu-Hong, Li, An-Ran, Guo, Yu, Dai, Yun, Wang, Ping, Zhou, Yi-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185139/
https://www.ncbi.nlm.nih.gov/pubmed/32276265
http://dx.doi.org/10.18632/aging.103031

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