Hypoxia increases mutational load of breast cancer cells through frameshift mutations

Tumor hypoxia-induced downregulation of DNA repair pathways and enhanced replication stress are potential sources of genomic instability. A plethora of genetic changes such as point mutations, large deletions and duplications, microsatellite and chromosomal instability have been discovered in cells...

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Detalles Bibliográficos
Autores principales: Hassan Venkatesh, Goutham, Bravo, Pamela, Shaaban Moustafa Elsayed, Walid, Amirtharaj, Francis, Wojtas, Bartosz, Abou Khouzam, Raefa, Hussein Nawafleh, Husam, Mallya, Sandeep, Satyamoorthy, Kapaettu, Dessen, Philippe, Rosselli, Filippo, Thiery, Jerome, Chouaib, Salem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185205/
https://www.ncbi.nlm.nih.gov/pubmed/32363122
http://dx.doi.org/10.1080/2162402X.2020.1750750

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