ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we uncover a novel mechanism of ADAM10- and ADAM17-mediated resistan...

Descripción completa

Detalles Bibliográficos
Autores principales: Orme, Jacob J., Jazieh, Khalid A., Xie, Tiancheng, Harrington, Susan, Liu, Xin, Ball, Matthew, Madden, Benjamin, Charlesworth, M. Cristine, Azam, Tariq U., Lucien, Fabrice, Wootla, Bharath, Li, Yanli, Villasboas, Jose Caetano, Mansfield, Aaron S., Dronca, Roxana S., Dong, Haidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185206/
https://www.ncbi.nlm.nih.gov/pubmed/32363112
http://dx.doi.org/10.1080/2162402X.2020.1744980

Ejemplares similares

Ejemplares similares