Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

Pancreatic islet insulin secretion is amplified by both metabolic and receptor‐mediated signaling pathways. The incretin‐mimetic and DPPIV inhibitor anti‐diabetic drugs increase insulin secretion, but in humans this can be variable both in vitro and in vivo. We examined the correlation of GLP‐1 indu...

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Detalles Bibliográficos
Autores principales: Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185381/
https://www.ncbi.nlm.nih.gov/pubmed/32339440
http://dx.doi.org/10.14814/phy2.14420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185381/
https://www.ncbi.nlm.nih.gov/pubmed/32339440
http://dx.doi.org/10.14814/phy2.14420

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