Cargando…
Do adaptive immune cells suppress or activate innate immunity?
Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection becau...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185383/ https://www.ncbi.nlm.nih.gov/pubmed/19058755 http://dx.doi.org/10.1016/j.it.2008.10.003 |
_version_ | 1783526748508389376 |
---|---|
author | Zhao, Jie Yang, Xuanming Auh, Sogyong L. Kim, Kwang Dong Tang, Hong Fu, Yang-Xin |
author_facet | Zhao, Jie Yang, Xuanming Auh, Sogyong L. Kim, Kwang Dong Tang, Hong Fu, Yang-Xin |
author_sort | Zhao, Jie |
collection | PubMed |
description | Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation. |
format | Online Article Text |
id | pubmed-7185383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71853832020-04-28 Do adaptive immune cells suppress or activate innate immunity? Zhao, Jie Yang, Xuanming Auh, Sogyong L. Kim, Kwang Dong Tang, Hong Fu, Yang-Xin Trends Immunol Article Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation. Elsevier Ltd. 2009-01 2008-12-06 /pmc/articles/PMC7185383/ /pubmed/19058755 http://dx.doi.org/10.1016/j.it.2008.10.003 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zhao, Jie Yang, Xuanming Auh, Sogyong L. Kim, Kwang Dong Tang, Hong Fu, Yang-Xin Do adaptive immune cells suppress or activate innate immunity? |
title | Do adaptive immune cells suppress or activate innate immunity? |
title_full | Do adaptive immune cells suppress or activate innate immunity? |
title_fullStr | Do adaptive immune cells suppress or activate innate immunity? |
title_full_unstemmed | Do adaptive immune cells suppress or activate innate immunity? |
title_short | Do adaptive immune cells suppress or activate innate immunity? |
title_sort | do adaptive immune cells suppress or activate innate immunity? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185383/ https://www.ncbi.nlm.nih.gov/pubmed/19058755 http://dx.doi.org/10.1016/j.it.2008.10.003 |
work_keys_str_mv | AT zhaojie doadaptiveimmunecellssuppressoractivateinnateimmunity AT yangxuanming doadaptiveimmunecellssuppressoractivateinnateimmunity AT auhsogyongl doadaptiveimmunecellssuppressoractivateinnateimmunity AT kimkwangdong doadaptiveimmunecellssuppressoractivateinnateimmunity AT tanghong doadaptiveimmunecellssuppressoractivateinnateimmunity AT fuyangxin doadaptiveimmunecellssuppressoractivateinnateimmunity |