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Do adaptive immune cells suppress or activate innate immunity?

Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection becau...

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Detalles Bibliográficos
Autores principales: Zhao, Jie, Yang, Xuanming, Auh, Sogyong L., Kim, Kwang Dong, Tang, Hong, Fu, Yang-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185383/
https://www.ncbi.nlm.nih.gov/pubmed/19058755
http://dx.doi.org/10.1016/j.it.2008.10.003
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author Zhao, Jie
Yang, Xuanming
Auh, Sogyong L.
Kim, Kwang Dong
Tang, Hong
Fu, Yang-Xin
author_facet Zhao, Jie
Yang, Xuanming
Auh, Sogyong L.
Kim, Kwang Dong
Tang, Hong
Fu, Yang-Xin
author_sort Zhao, Jie
collection PubMed
description Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation.
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spelling pubmed-71853832020-04-28 Do adaptive immune cells suppress or activate innate immunity? Zhao, Jie Yang, Xuanming Auh, Sogyong L. Kim, Kwang Dong Tang, Hong Fu, Yang-Xin Trends Immunol Article Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation. Elsevier Ltd. 2009-01 2008-12-06 /pmc/articles/PMC7185383/ /pubmed/19058755 http://dx.doi.org/10.1016/j.it.2008.10.003 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhao, Jie
Yang, Xuanming
Auh, Sogyong L.
Kim, Kwang Dong
Tang, Hong
Fu, Yang-Xin
Do adaptive immune cells suppress or activate innate immunity?
title Do adaptive immune cells suppress or activate innate immunity?
title_full Do adaptive immune cells suppress or activate innate immunity?
title_fullStr Do adaptive immune cells suppress or activate innate immunity?
title_full_unstemmed Do adaptive immune cells suppress or activate innate immunity?
title_short Do adaptive immune cells suppress or activate innate immunity?
title_sort do adaptive immune cells suppress or activate innate immunity?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185383/
https://www.ncbi.nlm.nih.gov/pubmed/19058755
http://dx.doi.org/10.1016/j.it.2008.10.003
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