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Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006
BACKGROUND: Human Bocavirus (HBoV), a new species of the genus parvovirus newly detected in 2005, seems to be a worldwide distributed pathogen among children with respiratory tract infection (prevalence 2%–18%). Recently published retrospective studies and one prospective birth cohort study suggest...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185401/ https://www.ncbi.nlm.nih.gov/pubmed/17851126 http://dx.doi.org/10.1016/j.jcv.2007.07.017 |
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author | Völz, Sebastian Schildgen, Oliver Klinkenberg, Dennis Ditt, Vanessa Müller, Andreas Tillmann, Ramona L. Kupfer, Bernd Bode, Udo Lentze, Michael J. Simon, Arne |
author_facet | Völz, Sebastian Schildgen, Oliver Klinkenberg, Dennis Ditt, Vanessa Müller, Andreas Tillmann, Ramona L. Kupfer, Bernd Bode, Udo Lentze, Michael J. Simon, Arne |
author_sort | Völz, Sebastian |
collection | PubMed |
description | BACKGROUND: Human Bocavirus (HBoV), a new species of the genus parvovirus newly detected in 2005, seems to be a worldwide distributed pathogen among children with respiratory tract infection (prevalence 2%–18%). Recently published retrospective studies and one prospective birth cohort study suggest that HBoV-primary infection occurs in infants. METHODS: Prospective single center study over one winter season (November 2005–May 2006) with hospitalized children without age restriction using PCR-based diagnostic methods. RESULTS: HBoV DNA was detected in 11 (2.8%) of 389 nasopharyngeal aspirates from symptomatic hospitalized children (median age 9.0 months; range: 3–17 months). RSV, HMPV, HCoV, and Influenza B were detected in 13.9% (n = 54), 5.1% (n = 20), 2.6% (n = 10), and 1.8% (n = 7), respectively. There was no influenza A DNA detected in any of the specimens. The clinical diagnoses were acute wheezing (bronchitis) in four patients, radiologically confirmed pneumonia in six patients (55%) and croup syndrome in one patient. In five to six patients with pneumonia, HBoV was the only pathogen detected. While no patient had to be mechanically ventilated, 73% needed oxygen supplementation. In four (36.4%) patients at least one other viral pathogen was found (plus RSV n = 3; 27.3%; Norovirus n = 1; 9.1%). CONCLUSION: HBoV causes severe respiratory tract infections in infants and young children. Its role as a copathogen and many other open questions has to be defined in further prospective studies. |
format | Online Article Text |
id | pubmed-7185401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71854012020-04-28 Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 Völz, Sebastian Schildgen, Oliver Klinkenberg, Dennis Ditt, Vanessa Müller, Andreas Tillmann, Ramona L. Kupfer, Bernd Bode, Udo Lentze, Michael J. Simon, Arne J Clin Virol Article BACKGROUND: Human Bocavirus (HBoV), a new species of the genus parvovirus newly detected in 2005, seems to be a worldwide distributed pathogen among children with respiratory tract infection (prevalence 2%–18%). Recently published retrospective studies and one prospective birth cohort study suggest that HBoV-primary infection occurs in infants. METHODS: Prospective single center study over one winter season (November 2005–May 2006) with hospitalized children without age restriction using PCR-based diagnostic methods. RESULTS: HBoV DNA was detected in 11 (2.8%) of 389 nasopharyngeal aspirates from symptomatic hospitalized children (median age 9.0 months; range: 3–17 months). RSV, HMPV, HCoV, and Influenza B were detected in 13.9% (n = 54), 5.1% (n = 20), 2.6% (n = 10), and 1.8% (n = 7), respectively. There was no influenza A DNA detected in any of the specimens. The clinical diagnoses were acute wheezing (bronchitis) in four patients, radiologically confirmed pneumonia in six patients (55%) and croup syndrome in one patient. In five to six patients with pneumonia, HBoV was the only pathogen detected. While no patient had to be mechanically ventilated, 73% needed oxygen supplementation. In four (36.4%) patients at least one other viral pathogen was found (plus RSV n = 3; 27.3%; Norovirus n = 1; 9.1%). CONCLUSION: HBoV causes severe respiratory tract infections in infants and young children. Its role as a copathogen and many other open questions has to be defined in further prospective studies. Elsevier B.V. 2007-11 2007-09-11 /pmc/articles/PMC7185401/ /pubmed/17851126 http://dx.doi.org/10.1016/j.jcv.2007.07.017 Text en Copyright © 2007 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Völz, Sebastian Schildgen, Oliver Klinkenberg, Dennis Ditt, Vanessa Müller, Andreas Tillmann, Ramona L. Kupfer, Bernd Bode, Udo Lentze, Michael J. Simon, Arne Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title | Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title_full | Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title_fullStr | Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title_full_unstemmed | Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title_short | Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006 |
title_sort | prospective study of human bocavirus (hbov) infection in a pediatric university hospital in germany 2005/2006 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185401/ https://www.ncbi.nlm.nih.gov/pubmed/17851126 http://dx.doi.org/10.1016/j.jcv.2007.07.017 |
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