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Neutrophil Diversity in Health and Disease

New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plastic...

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Autores principales: Silvestre-Roig, Carlos, Fridlender, Zvi G., Glogauer, Michael, Scapini, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185435/
https://www.ncbi.nlm.nih.gov/pubmed/31160207
http://dx.doi.org/10.1016/j.it.2019.04.012
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author Silvestre-Roig, Carlos
Fridlender, Zvi G.
Glogauer, Michael
Scapini, Patrizia
author_facet Silvestre-Roig, Carlos
Fridlender, Zvi G.
Glogauer, Michael
Scapini, Patrizia
author_sort Silvestre-Roig, Carlos
collection PubMed
description New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.
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spelling pubmed-71854352020-04-28 Neutrophil Diversity in Health and Disease Silvestre-Roig, Carlos Fridlender, Zvi G. Glogauer, Michael Scapini, Patrizia Trends Immunol Feature Review New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches. Elsevier Ltd. 2019-07 2019-05-31 /pmc/articles/PMC7185435/ /pubmed/31160207 http://dx.doi.org/10.1016/j.it.2019.04.012 Text en © 2019 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Feature Review
Silvestre-Roig, Carlos
Fridlender, Zvi G.
Glogauer, Michael
Scapini, Patrizia
Neutrophil Diversity in Health and Disease
title Neutrophil Diversity in Health and Disease
title_full Neutrophil Diversity in Health and Disease
title_fullStr Neutrophil Diversity in Health and Disease
title_full_unstemmed Neutrophil Diversity in Health and Disease
title_short Neutrophil Diversity in Health and Disease
title_sort neutrophil diversity in health and disease
topic Feature Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185435/
https://www.ncbi.nlm.nih.gov/pubmed/31160207
http://dx.doi.org/10.1016/j.it.2019.04.012
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