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CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)

Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus with high mortality. Immune suppression is thought to be crucial in disease progression. However, data on immune responses during SFTS are scarce. This study aimed to evaluate the c...

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Autores principales: Li, Meng-Meng, Zhang, Wen-Jing, Weng, Xiu-Fang, Li, Ming-Yue, Liu, Jia, Xiong, Yan, Xiong, Shu-E, Zou, Cong-Cong, Wang, Hua, Lu, Meng-ji, Yang, Dong-Liang, Peng, Cheng, Zheng, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185468/
https://www.ncbi.nlm.nih.gov/pubmed/30036637
http://dx.doi.org/10.1016/j.clim.2018.07.009
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author Li, Meng-Meng
Zhang, Wen-Jing
Weng, Xiu-Fang
Li, Ming-Yue
Liu, Jia
Xiong, Yan
Xiong, Shu-E
Zou, Cong-Cong
Wang, Hua
Lu, Meng-ji
Yang, Dong-Liang
Peng, Cheng
Zheng, Xin
author_facet Li, Meng-Meng
Zhang, Wen-Jing
Weng, Xiu-Fang
Li, Ming-Yue
Liu, Jia
Xiong, Yan
Xiong, Shu-E
Zou, Cong-Cong
Wang, Hua
Lu, Meng-ji
Yang, Dong-Liang
Peng, Cheng
Zheng, Xin
author_sort Li, Meng-Meng
collection PubMed
description Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus with high mortality. Immune suppression is thought to be crucial in disease progression. However, data on immune responses during SFTS are scarce. This study aimed to evaluate the changes in CD4 T-cell subsets throughout the entirety of infection and analyse their relationships with disease severity in SFTS patients. In parallel with CD4 T-cell depletion, decreased Th1, Th2 and Treg numbers, but comparable Th17-cell numbers, were observed in deceased patients compared with those in surviving patients. Additionally, increased Th2 and Th17-cell percentages in the residual CD4 T-cell population led to aberrant Th2/Th1 and Th17/Treg ratios, which were positively correlated with disease severity. Collectively, our data indicated that CD4 T-cell deficiency, Th2 and Th17 bias were closely correlated with the severity of SFTS, indicating therapeutic potential of early immune interventions to ameliorate disease severity.
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spelling pubmed-71854682020-04-28 CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS) Li, Meng-Meng Zhang, Wen-Jing Weng, Xiu-Fang Li, Ming-Yue Liu, Jia Xiong, Yan Xiong, Shu-E Zou, Cong-Cong Wang, Hua Lu, Meng-ji Yang, Dong-Liang Peng, Cheng Zheng, Xin Clin Immunol Article Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease caused by a novel bunyavirus with high mortality. Immune suppression is thought to be crucial in disease progression. However, data on immune responses during SFTS are scarce. This study aimed to evaluate the changes in CD4 T-cell subsets throughout the entirety of infection and analyse their relationships with disease severity in SFTS patients. In parallel with CD4 T-cell depletion, decreased Th1, Th2 and Treg numbers, but comparable Th17-cell numbers, were observed in deceased patients compared with those in surviving patients. Additionally, increased Th2 and Th17-cell percentages in the residual CD4 T-cell population led to aberrant Th2/Th1 and Th17/Treg ratios, which were positively correlated with disease severity. Collectively, our data indicated that CD4 T-cell deficiency, Th2 and Th17 bias were closely correlated with the severity of SFTS, indicating therapeutic potential of early immune interventions to ameliorate disease severity. Published by Elsevier Inc. 2018-10 2018-07-20 /pmc/articles/PMC7185468/ /pubmed/30036637 http://dx.doi.org/10.1016/j.clim.2018.07.009 Text en © 2018 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Meng-Meng
Zhang, Wen-Jing
Weng, Xiu-Fang
Li, Ming-Yue
Liu, Jia
Xiong, Yan
Xiong, Shu-E
Zou, Cong-Cong
Wang, Hua
Lu, Meng-ji
Yang, Dong-Liang
Peng, Cheng
Zheng, Xin
CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title_full CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title_fullStr CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title_full_unstemmed CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title_short CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
title_sort cd4 t cell loss and th2 and th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (sfts)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185468/
https://www.ncbi.nlm.nih.gov/pubmed/30036637
http://dx.doi.org/10.1016/j.clim.2018.07.009
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