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Infections associated with haemophagocytic syndrome

Haemophagocytic syndrome or haemophagocytic lymphohistiocytosis is a rare disease that is often fatal despite treatment. Haemophagocytic syndrome is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of lymphocytes or histiocytes with uncontrolled...

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Autores principales: Rouphael, Nadine G, Talati, Naasha J, Vaughan, Camille, Cunningham, Kelly, Moreira, Roger, Gould, Carolyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185531/
https://www.ncbi.nlm.nih.gov/pubmed/18045564
http://dx.doi.org/10.1016/S1473-3099(07)70290-6
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author Rouphael, Nadine G
Talati, Naasha J
Vaughan, Camille
Cunningham, Kelly
Moreira, Roger
Gould, Carolyn
author_facet Rouphael, Nadine G
Talati, Naasha J
Vaughan, Camille
Cunningham, Kelly
Moreira, Roger
Gould, Carolyn
author_sort Rouphael, Nadine G
collection PubMed
description Haemophagocytic syndrome or haemophagocytic lymphohistiocytosis is a rare disease that is often fatal despite treatment. Haemophagocytic syndrome is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of lymphocytes or histiocytes with uncontrolled haemophagocytosis and cytokine overproduction. The syndrome is characterised by fever, hepatosplenomegaly, cytopenias, liver dysfunction, and hyperferritinaemia. Haemophagocytic syndrome can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Infections associated with haemophagocytic syndrome are most frequently caused by viruses, particularly Epstein-Barr virus (EBV). We present a case of EBV-associated haemophagocytic syndrome in a young adult with no known immunosuppression. We briefly review haemophagocytic syndrome and then discuss its associated infections, particularly EBV and other herpes viruses, HIV, influenza, parvovirus, and hepatitis viruses, as well as bacterial, fungal, and parasitic organisms.
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spelling pubmed-71855312020-04-28 Infections associated with haemophagocytic syndrome Rouphael, Nadine G Talati, Naasha J Vaughan, Camille Cunningham, Kelly Moreira, Roger Gould, Carolyn Lancet Infect Dis Article Haemophagocytic syndrome or haemophagocytic lymphohistiocytosis is a rare disease that is often fatal despite treatment. Haemophagocytic syndrome is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of lymphocytes or histiocytes with uncontrolled haemophagocytosis and cytokine overproduction. The syndrome is characterised by fever, hepatosplenomegaly, cytopenias, liver dysfunction, and hyperferritinaemia. Haemophagocytic syndrome can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Infections associated with haemophagocytic syndrome are most frequently caused by viruses, particularly Epstein-Barr virus (EBV). We present a case of EBV-associated haemophagocytic syndrome in a young adult with no known immunosuppression. We briefly review haemophagocytic syndrome and then discuss its associated infections, particularly EBV and other herpes viruses, HIV, influenza, parvovirus, and hepatitis viruses, as well as bacterial, fungal, and parasitic organisms. Elsevier Ltd. 2007-12 2007-11-26 /pmc/articles/PMC7185531/ /pubmed/18045564 http://dx.doi.org/10.1016/S1473-3099(07)70290-6 Text en Copyright © 2007 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rouphael, Nadine G
Talati, Naasha J
Vaughan, Camille
Cunningham, Kelly
Moreira, Roger
Gould, Carolyn
Infections associated with haemophagocytic syndrome
title Infections associated with haemophagocytic syndrome
title_full Infections associated with haemophagocytic syndrome
title_fullStr Infections associated with haemophagocytic syndrome
title_full_unstemmed Infections associated with haemophagocytic syndrome
title_short Infections associated with haemophagocytic syndrome
title_sort infections associated with haemophagocytic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185531/
https://www.ncbi.nlm.nih.gov/pubmed/18045564
http://dx.doi.org/10.1016/S1473-3099(07)70290-6
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