IFITM proteins — cellular inhibitors of viral entry

Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry...

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Detalles Bibliográficos
Autores principales: Smith, SE, Weston, S, Kellam, P, Marsh, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185728/
https://www.ncbi.nlm.nih.gov/pubmed/24480526
http://dx.doi.org/10.1016/j.coviro.2013.11.004
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author Smith, SE
Weston, S
Kellam, P
Marsh, M
author_facet Smith, SE
Weston, S
Kellam, P
Marsh, M
author_sort Smith, SE
collection PubMed
description Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.
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spelling pubmed-71857282020-04-28 IFITM proteins — cellular inhibitors of viral entry Smith, SE Weston, S Kellam, P Marsh, M Curr Opin Virol Article Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research. Elsevier B.V. 2014-02 2014-01-28 /pmc/articles/PMC7185728/ /pubmed/24480526 http://dx.doi.org/10.1016/j.coviro.2013.11.004 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Smith, SE
Weston, S
Kellam, P
Marsh, M
IFITM proteins — cellular inhibitors of viral entry
title IFITM proteins — cellular inhibitors of viral entry
title_full IFITM proteins — cellular inhibitors of viral entry
title_fullStr IFITM proteins — cellular inhibitors of viral entry
title_full_unstemmed IFITM proteins — cellular inhibitors of viral entry
title_short IFITM proteins — cellular inhibitors of viral entry
title_sort ifitm proteins — cellular inhibitors of viral entry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185728/
https://www.ncbi.nlm.nih.gov/pubmed/24480526
http://dx.doi.org/10.1016/j.coviro.2013.11.004
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