Cargando…
Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia
BACKGROUND: Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood. OBJECTIVE: To determine the distribution of HRV specie...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185749/ https://www.ncbi.nlm.nih.gov/pubmed/20728404 http://dx.doi.org/10.1016/j.jcv.2010.07.013 |
_version_ | 1783526820956602368 |
---|---|
author | Xiang, Zichun Gonzalez, Richard Xie, Zhengde Xiao, Yan Liu, Jun Chen, Lan Liu, Chunyan Zhang, Jing Ren, Lili Vernet, Guy Paranhos-Baccalà, Gláucia Shen, Kunling Jin, Qi Wang, Jianwei |
author_facet | Xiang, Zichun Gonzalez, Richard Xie, Zhengde Xiao, Yan Liu, Jun Chen, Lan Liu, Chunyan Zhang, Jing Ren, Lili Vernet, Guy Paranhos-Baccalà, Gláucia Shen, Kunling Jin, Qi Wang, Jianwei |
author_sort | Xiang, Zichun |
collection | PubMed |
description | BACKGROUND: Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood. OBJECTIVE: To determine the distribution of HRV species and their roles in children hospitalized with CAP in Beijing, China. STUDY DESIGN: Nasopharyngeal aspirates were collected between April 2007 and March 2008 from 554 children with a primary diagnosis of CAP. HRVs in the clinical samples were detected by RT-PCR and by sequencing. Infections with other respiratory viruses were identified by PCR. RESULTS: HRVs were detected in 99 patients (17.87%). Among these patients, 51.52% tested positive for HRV-A, 38.38% for HRV-C, and 10.10% for HRV-B. HRVs were detected throughout the study period. The monthly distribution of HRV infections varied with HRV species. Median age, gender, symptoms, severity, and duration of hospitalization for single HRV-C infections were similar to those observed for single HRV-A infections. Co-infections with other respiratory viruses were detected in 57.58% of the HRV-positive children. HRV/RSV dual infections were correlated with a higher frequency of shortness of breath (HRV-A group, P(2tail) = 0.01; HRV-C group, P(2tail) = 0.015) and lower median ages (HRV-A group, P(2tail) = 0.049; HRV-C group, P(2tail) = 0.009). CONCLUSION: Our study shows that HRV-C strains circulate at a prevalence intermediate between HRV-A and HRV-B. The severity of clinical manifestations for HRV-C is comparable to that for HRV-A in children with CAP. These findings point to an important role of both HRV-A and HRV-C in pediatric CAP. |
format | Online Article Text |
id | pubmed-7185749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71857492020-04-28 Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia Xiang, Zichun Gonzalez, Richard Xie, Zhengde Xiao, Yan Liu, Jun Chen, Lan Liu, Chunyan Zhang, Jing Ren, Lili Vernet, Guy Paranhos-Baccalà, Gláucia Shen, Kunling Jin, Qi Wang, Jianwei J Clin Virol Article BACKGROUND: Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood. OBJECTIVE: To determine the distribution of HRV species and their roles in children hospitalized with CAP in Beijing, China. STUDY DESIGN: Nasopharyngeal aspirates were collected between April 2007 and March 2008 from 554 children with a primary diagnosis of CAP. HRVs in the clinical samples were detected by RT-PCR and by sequencing. Infections with other respiratory viruses were identified by PCR. RESULTS: HRVs were detected in 99 patients (17.87%). Among these patients, 51.52% tested positive for HRV-A, 38.38% for HRV-C, and 10.10% for HRV-B. HRVs were detected throughout the study period. The monthly distribution of HRV infections varied with HRV species. Median age, gender, symptoms, severity, and duration of hospitalization for single HRV-C infections were similar to those observed for single HRV-A infections. Co-infections with other respiratory viruses were detected in 57.58% of the HRV-positive children. HRV/RSV dual infections were correlated with a higher frequency of shortness of breath (HRV-A group, P(2tail) = 0.01; HRV-C group, P(2tail) = 0.015) and lower median ages (HRV-A group, P(2tail) = 0.049; HRV-C group, P(2tail) = 0.009). CONCLUSION: Our study shows that HRV-C strains circulate at a prevalence intermediate between HRV-A and HRV-B. The severity of clinical manifestations for HRV-C is comparable to that for HRV-A in children with CAP. These findings point to an important role of both HRV-A and HRV-C in pediatric CAP. Elsevier B.V. 2010-10 2010-08-21 /pmc/articles/PMC7185749/ /pubmed/20728404 http://dx.doi.org/10.1016/j.jcv.2010.07.013 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Xiang, Zichun Gonzalez, Richard Xie, Zhengde Xiao, Yan Liu, Jun Chen, Lan Liu, Chunyan Zhang, Jing Ren, Lili Vernet, Guy Paranhos-Baccalà, Gláucia Shen, Kunling Jin, Qi Wang, Jianwei Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title | Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title_full | Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title_fullStr | Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title_full_unstemmed | Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title_short | Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia |
title_sort | human rhinovirus c infections mirror those of human rhinovirus a in children with community-acquired pneumonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185749/ https://www.ncbi.nlm.nih.gov/pubmed/20728404 http://dx.doi.org/10.1016/j.jcv.2010.07.013 |
work_keys_str_mv | AT xiangzichun humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT gonzalezrichard humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT xiezhengde humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT xiaoyan humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT liujun humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT chenlan humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT liuchunyan humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT zhangjing humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT renlili humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT vernetguy humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT paranhosbaccalaglaucia humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT shenkunling humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT jinqi humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia AT wangjianwei humanrhinoviruscinfectionsmirrorthoseofhumanrhinovirusainchildrenwithcommunityacquiredpneumonia |