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The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts

Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial act...

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Autores principales: da Cunha, Nicolau B., Cobacho, Nicole B., Viana, Juliane F.C., Lima, Loiane A., Sampaio, Kamila B.O., Dohms, Stephan S.M., Ferreira, Arthur C.R., de la Fuente-Núñez, César, Costa, Fabrício F., Franco, Octávio L., Dias, Simoni C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185764/
https://www.ncbi.nlm.nih.gov/pubmed/27890668
http://dx.doi.org/10.1016/j.drudis.2016.10.017
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author da Cunha, Nicolau B.
Cobacho, Nicole B.
Viana, Juliane F.C.
Lima, Loiane A.
Sampaio, Kamila B.O.
Dohms, Stephan S.M.
Ferreira, Arthur C.R.
de la Fuente-Núñez, César
Costa, Fabrício F.
Franco, Octávio L.
Dias, Simoni C.
author_facet da Cunha, Nicolau B.
Cobacho, Nicole B.
Viana, Juliane F.C.
Lima, Loiane A.
Sampaio, Kamila B.O.
Dohms, Stephan S.M.
Ferreira, Arthur C.R.
de la Fuente-Núñez, César
Costa, Fabrício F.
Franco, Octávio L.
Dias, Simoni C.
author_sort da Cunha, Nicolau B.
collection PubMed
description Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis.
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spelling pubmed-71857642020-04-28 The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts da Cunha, Nicolau B. Cobacho, Nicole B. Viana, Juliane F.C. Lima, Loiane A. Sampaio, Kamila B.O. Dohms, Stephan S.M. Ferreira, Arthur C.R. de la Fuente-Núñez, César Costa, Fabrício F. Franco, Octávio L. Dias, Simoni C. Drug Discov Today Article Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide. Antimicrobial peptides (AMPs) are multifunctional effectors of the innate immune system of mucosal surfaces and present antimicrobial activity against a range of pathogenic viruses, bacteria, and fungi. However, the discovery and development of new antibacterial drugs is a crucial step to overcome the great challenge posed by the emergence of antibiotic resistance. In this review, we outline recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design. In addition, we describe recent progress made to overcome some of the major limitations that have hindered peptide biosynthesis. Elsevier Ltd. 2017-02 2016-11-23 /pmc/articles/PMC7185764/ /pubmed/27890668 http://dx.doi.org/10.1016/j.drudis.2016.10.017 Text en © 2016 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
da Cunha, Nicolau B.
Cobacho, Nicole B.
Viana, Juliane F.C.
Lima, Loiane A.
Sampaio, Kamila B.O.
Dohms, Stephan S.M.
Ferreira, Arthur C.R.
de la Fuente-Núñez, César
Costa, Fabrício F.
Franco, Octávio L.
Dias, Simoni C.
The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title_full The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title_fullStr The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title_full_unstemmed The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title_short The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
title_sort next generation of antimicrobial peptides (amps) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185764/
https://www.ncbi.nlm.nih.gov/pubmed/27890668
http://dx.doi.org/10.1016/j.drudis.2016.10.017
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