Cargando…

Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis

Human parainfluenza virus (HPIV) infection as an aetiology of acute viral myocarditis is rare, with only few cases reported in the literature to date. Here we report a case of fulminant HPIV-2 myocarditis in a 47 year-old man with viraemia who was successfully treated with intravenous ribavirin and...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalimuddin, Shirin, Sessions, October M., Hou, Yan’An, Ooi, Eng Eong, Sim, David, Cumaraswamy, Sivathasan, Tan, Teing Ee, Lai, Siang Hui, Low, Chian Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185820/
https://www.ncbi.nlm.nih.gov/pubmed/23137789
http://dx.doi.org/10.1016/j.jcv.2012.10.005
_version_ 1783526831915270144
author Kalimuddin, Shirin
Sessions, October M.
Hou, Yan’An
Ooi, Eng Eong
Sim, David
Cumaraswamy, Sivathasan
Tan, Teing Ee
Lai, Siang Hui
Low, Chian Yong
author_facet Kalimuddin, Shirin
Sessions, October M.
Hou, Yan’An
Ooi, Eng Eong
Sim, David
Cumaraswamy, Sivathasan
Tan, Teing Ee
Lai, Siang Hui
Low, Chian Yong
author_sort Kalimuddin, Shirin
collection PubMed
description Human parainfluenza virus (HPIV) infection as an aetiology of acute viral myocarditis is rare, with only few cases reported in the literature to date. Here we report a case of fulminant HPIV-2 myocarditis in a 47 year-old man with viraemia who was successfully treated with intravenous ribavirin and intravenous immunoglobulin (IVIG). There are currently no recommendations on the treatment of HPIV myocarditis. We are, to our knowledge, the first to report a patient with a documented HPIV-2 viraemia that subsequently cleared after the initiation of antiviral therapy. Although it is difficult to definitively attribute the patient's clinical improvement to ribavirin or IVIG alone, our case does suggest that clinicians may wish to consider initiating ribavirin and IVIG in patients with HPIV myocarditis and persistent viraemia not responding to supportive measures alone.
format Online
Article
Text
id pubmed-7185820
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-71858202020-04-28 Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis Kalimuddin, Shirin Sessions, October M. Hou, Yan’An Ooi, Eng Eong Sim, David Cumaraswamy, Sivathasan Tan, Teing Ee Lai, Siang Hui Low, Chian Yong J Clin Virol Article Human parainfluenza virus (HPIV) infection as an aetiology of acute viral myocarditis is rare, with only few cases reported in the literature to date. Here we report a case of fulminant HPIV-2 myocarditis in a 47 year-old man with viraemia who was successfully treated with intravenous ribavirin and intravenous immunoglobulin (IVIG). There are currently no recommendations on the treatment of HPIV myocarditis. We are, to our knowledge, the first to report a patient with a documented HPIV-2 viraemia that subsequently cleared after the initiation of antiviral therapy. Although it is difficult to definitively attribute the patient's clinical improvement to ribavirin or IVIG alone, our case does suggest that clinicians may wish to consider initiating ribavirin and IVIG in patients with HPIV myocarditis and persistent viraemia not responding to supportive measures alone. Elsevier B.V. 2013-01 2012-11-05 /pmc/articles/PMC7185820/ /pubmed/23137789 http://dx.doi.org/10.1016/j.jcv.2012.10.005 Text en Copyright © 2012 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kalimuddin, Shirin
Sessions, October M.
Hou, Yan’An
Ooi, Eng Eong
Sim, David
Cumaraswamy, Sivathasan
Tan, Teing Ee
Lai, Siang Hui
Low, Chian Yong
Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title_full Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title_fullStr Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title_full_unstemmed Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title_short Successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
title_sort successful clearance of human parainfluenza virus type 2 viraemia with intravenous ribavirin and immunoglobulin in a patient with acute myocarditis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185820/
https://www.ncbi.nlm.nih.gov/pubmed/23137789
http://dx.doi.org/10.1016/j.jcv.2012.10.005
work_keys_str_mv AT kalimuddinshirin successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT sessionsoctoberm successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT houyanan successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT ooiengeong successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT simdavid successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT cumaraswamysivathasan successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT tanteingee successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT laisianghui successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis
AT lowchianyong successfulclearanceofhumanparainfluenzavirustype2viraemiawithintravenousribavirinandimmunoglobulininapatientwithacutemyocarditis