New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery

In the postgenomic era, computer-aided drug design (CADD) has considerably extended its range of applications, spanning almost all stages in the drug discovery pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials. Two new technologies of CA...

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Detalles Bibliográficos
Autores principales: Tang, Yun, Zhu, Weiliang, Chen, Kaixian, Jiang, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Medicinal Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185835/
https://www.ncbi.nlm.nih.gov/pubmed/24980533
http://dx.doi.org/10.1016/j.ddtec.2006.09.004
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author Tang, Yun
Zhu, Weiliang
Chen, Kaixian
Jiang, Hualiang
author_facet Tang, Yun
Zhu, Weiliang
Chen, Kaixian
Jiang, Hualiang
author_sort Tang, Yun
collection PubMed
description In the postgenomic era, computer-aided drug design (CADD) has considerably extended its range of applications, spanning almost all stages in the drug discovery pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials. Two new technologies of CADD associated with target identification and new chemical entity discovery will be the focus of this review.
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spelling pubmed-71858352020-04-28 New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery Tang, Yun Zhu, Weiliang Chen, Kaixian Jiang, Hualiang Drug Discov Today Technol Medicinal Chemistry In the postgenomic era, computer-aided drug design (CADD) has considerably extended its range of applications, spanning almost all stages in the drug discovery pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials. Two new technologies of CADD associated with target identification and new chemical entity discovery will be the focus of this review. Elsevier Ltd. 2006 2006-09-26 /pmc/articles/PMC7185835/ /pubmed/24980533 http://dx.doi.org/10.1016/j.ddtec.2006.09.004 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Medicinal Chemistry
Tang, Yun
Zhu, Weiliang
Chen, Kaixian
Jiang, Hualiang
New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title_full New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title_fullStr New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title_full_unstemmed New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title_short New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery
title_sort new technologies in computer-aided drug design: toward target identification and new chemical entity discovery
topic Medicinal Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185835/
https://www.ncbi.nlm.nih.gov/pubmed/24980533
http://dx.doi.org/10.1016/j.ddtec.2006.09.004
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AT jianghualiang newtechnologiesincomputeraideddrugdesigntowardtargetidentificationandnewchemicalentitydiscovery

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