Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target

The 3C protease from foot-and-mouth disease virus (FMDV 3C(pro)) is critical for viral pathogenesis, having vital roles in both the processing of the polyprotein precursor and RNA replication. Although recent structural and functional studies have revealed new insights into the mechanism and functio...

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Detalles Bibliográficos
Autores principales: Curry, Stephen, Roqué-Rosell, Núria, Zunszain, Patricia A., Leatherbarrow, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Molecules in Focus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185863/
https://www.ncbi.nlm.nih.gov/pubmed/16979372
http://dx.doi.org/10.1016/j.biocel.2006.07.006
Descripción
Sumario:The 3C protease from foot-and-mouth disease virus (FMDV 3C(pro)) is critical for viral pathogenesis, having vital roles in both the processing of the polyprotein precursor and RNA replication. Although recent structural and functional studies have revealed new insights into the mechanism and function of the enzyme, key questions remain that must be addressed before the potential of FMDV 3C(pro) as an antiviral drug target can be realised.

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