Cargando…

Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion

The large GTPase Dynamin 2 (Dyn2) is known to increase the invasiveness of pancreatic cancer tumor cells, but the mechanisms by which Dyn2 regulates changes in the actin cytoskeleton to drive cell migration are still unclear. Here we report that a direct interaction between Dyn2 and the actin-bundli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burton, Kevin M., Cao, Hong, Chen, Jing, Qiang, Li, Krueger, Eugene W., Johnson, Katherine M., Bamlet, William R., Zhang, Lizhi, McNiven, Mark A., Razidlo, Gina L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185896/ https://www.ncbi.nlm.nih.gov/pubmed/31967944 http://dx.doi.org/10.1091/mbc.E19-07-0395

Ejemplares similares

Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking
por: Burton, Kevin M., et al.
Publicado: (2021)

Increased Expression of the Large GTPase Dynamin 2 Potentiates Metastatic Migration and Invasion of Pancreatic Ductal Carcinoma
por: Eppinga, Robbin D., et al.
Publicado: (2011)

Dynamin-mediated Internalization of Caveolae
por: Henley, John R., et al.
Publicado: (1998)

Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process
por: Cao, Hong, et al.
Publicado: (2015)

Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1
por: Qiang, Li, et al.
Publicado: (2019)

Dynamin 2 Mediates PDGFRα-SHP-2-Promoted Glioblastoma Growth and Invasion
por: Feng, H, et al.
Publicado: (2011)

Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells
por: Cao, Hong, et al.
Publicado: (2021)

Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape
por: McNiven, Mark A., et al.
Publicado: (2000)

The anti-viral dynamin family member MxB participates in mitochondrial integrity
por: Cao, Hong, et al.
Publicado: (2020)

Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes
por: Schulze, Ryan J., et al.
Publicado: (2013)

Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
por: Gutierrez-Ruiz, Omar L., et al.
Publicado: (2023)

Dynamin 2 Is Required for Phagocytosis in Macrophages
por: Gold, Elizabeth S., et al.
Publicado: (1999)

A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src
por: Wang, Yu, et al.
Publicado: (2011)

A Novel Dynamin-like Protein Associates with Cytoplasmic Vesicles and Tubules of the Endoplasmic Reticulum in Mammalian Cells
por: Yoon, Yisang, et al.
Publicado: (1998)

A Functional Link between Dynamin and the Actin Cytoskeleton at Podosomes
por: Ochoa, Gian-Carlo, et al.
Publicado: (2000)

Ethanol‐induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity
por: Rasineni, Karuna, et al.
Publicado: (2017)

Characterisation of Schizosaccharomyces pombe α-actinin
por: Addario, Barbara, et al.
Publicado: (2016)

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of α-actinin
por: Klaavuniemi, Tuula, et al.
Publicado: (2009)

Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer
por: Dasgupta, Aneesha, et al.
Publicado: (2022)

Calcium affinity of human α-actinin 1
por: Backman, Lars
Publicado: (2015)

The Structure and Regulation of Human Muscle α-Actinin
por: Ribeiro, Euripedes de Almeida, et al.
Publicado: (2014)

The domain structure of Entamoeba α-actinin2
por: Addario, Barbara, et al.
Publicado: (2010)

Podocyte Injury Associated with Mutant α-Actinin-4
por: Cybulsky, Andrey V., et al.
Publicado: (2011)

Limited digestion of α-actinin in the presence of F-actin
por: Jia, You, et al.
Publicado: (2011)

α-Actinin-4 Enhances Colorectal Cancer Cell Invasion by Suppressing Focal Adhesion Maturation
por: Fukumoto, Miki, et al.
Publicado: (2015)

Direct lysosome-based autophagy of lipid droplets in hepatocytes
por: Schulze, Ryan J., et al.
Publicado: (2020)

Distribution of flourescently labeled α-actinin in living and fixed fibroblasts
por: Feramisco,, et al.
Publicado: (1980)

HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment
por: Trulsson, Maria, et al.
Publicado: (2011)

Isoform-Specific Contributions of α-Actinin to Glioma Cell Mechanobiology
por: Sen, Shamik, et al.
Publicado: (2009)

α-Actinin-3: Why Gene Loss Is an Evolutionary Gain
por: Ivarsson, Niklas, et al.
Publicado: (2015)

The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus
por: Ninomiya, Masashi, et al.
Publicado: (2021)

Multiple Dynamin family members collaborate to drive mitochondrial division
por: Lee, Jason E., et al.
Publicado: (2016)

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex
por: Wang, Yu, et al.
Publicado: (2012)

α-Actinin and Filamin Cooperatively Enhance the Stiffness of Actin Filament Networks
por: Esue, Osigwe, et al.
Publicado: (2009)

α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts
por: Shao, Hanshuang, et al.
Publicado: (2010)

Neisseria meningitidis Opc invasin binds to the cytoskeletal protein α-actinin
por: Sa E Cunha, Claudia, et al.
Publicado: (2009)

The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis
por: Youinou, Pierre, et al.
Publicado: (2009)

Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans
por: Houweling, P J, et al.
Publicado: (2017)

The Cell Biology of Metastatic Invasion in Pancreatic Cancer: Updates and Mechanistic Insights
por: Joshi, Vidhu B., et al.
Publicado: (2023)

AB077. The expression and clinical significance of α-actinin-1 in prostate cancer and benign prostatic hyperplasia
por: Cao, Feng-Hong
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tnnkekkb37bhldn00eq5c6or8n