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Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

Cytoplasmic dynein is activated by forming a complex with dynactin and the adaptor protein BicD2. We used interferometric scattering (iSCAT) microscopy to track dynein–dynactin–BicD2 (DDB) complexes in vitro and developed a regression-based algorithm to classify switching between processive, diffusi...

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Detalles Bibliográficos
Autores principales:	Feng, Qingzhou, Gicking, Allison M., Hancock, William O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185967/ https://www.ncbi.nlm.nih.gov/pubmed/32023147 http://dx.doi.org/10.1091/mbc.E19-09-0495

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