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Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy

Objective: The inflammatory and vascular disorders have been proposed in the pathogenesis of Bell’s palsy (BP). Several studies investigated the role of inflammation and ischemia in BP using white blood cell (WBC) count and its subtypes. Here, we aimed to investigate lactate dehydrogenase (LDH), neu...

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Autores principales: Baklacı, Deniz, Guler, İsmail, Kuzucu, İhsan, Kum, Rauf Oğuzhan, Özcan, Müge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186107/
https://www.ncbi.nlm.nih.gov/pubmed/32351812
http://dx.doi.org/10.7759/cureus.7432
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author Baklacı, Deniz
Guler, İsmail
Kuzucu, İhsan
Kum, Rauf Oğuzhan
Özcan, Müge
author_facet Baklacı, Deniz
Guler, İsmail
Kuzucu, İhsan
Kum, Rauf Oğuzhan
Özcan, Müge
author_sort Baklacı, Deniz
collection PubMed
description Objective: The inflammatory and vascular disorders have been proposed in the pathogenesis of Bell’s palsy (BP). Several studies investigated the role of inflammation and ischemia in BP using white blood cell (WBC) count and its subtypes. Here, we aimed to investigate lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet-lymphocyte ratio (PLR) in BP. Methods: The study was conducted on 76 patients with BP and 60 healthy controls. The comparison of LDH, NLR, MPV, and PLR was made between groups. The relationships between LDH, NLR, MPV, and PLR were also investigated. Results: The mean LDH concentrations and NLR were significantly high in BP group than in control group (p < 0.01, p < 0.05, respectively). There was no significant difference between groups in MPV and PLR (p = 0.195, p = 0.263, respectively). Conclusion: Our results support the diagnostic value of high LDH concentrations in BP patients. Further studies are needed to investigate the relationship between LDH and the severity and prognosis of BP.
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spelling pubmed-71861072020-04-29 Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy Baklacı, Deniz Guler, İsmail Kuzucu, İhsan Kum, Rauf Oğuzhan Özcan, Müge Cureus Otolaryngology Objective: The inflammatory and vascular disorders have been proposed in the pathogenesis of Bell’s palsy (BP). Several studies investigated the role of inflammation and ischemia in BP using white blood cell (WBC) count and its subtypes. Here, we aimed to investigate lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet-lymphocyte ratio (PLR) in BP. Methods: The study was conducted on 76 patients with BP and 60 healthy controls. The comparison of LDH, NLR, MPV, and PLR was made between groups. The relationships between LDH, NLR, MPV, and PLR were also investigated. Results: The mean LDH concentrations and NLR were significantly high in BP group than in control group (p < 0.01, p < 0.05, respectively). There was no significant difference between groups in MPV and PLR (p = 0.195, p = 0.263, respectively). Conclusion: Our results support the diagnostic value of high LDH concentrations in BP patients. Further studies are needed to investigate the relationship between LDH and the severity and prognosis of BP. Cureus 2020-03-27 /pmc/articles/PMC7186107/ /pubmed/32351812 http://dx.doi.org/10.7759/cureus.7432 Text en Copyright © 2020, Baklacı et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Otolaryngology
Baklacı, Deniz
Guler, İsmail
Kuzucu, İhsan
Kum, Rauf Oğuzhan
Özcan, Müge
Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title_full Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title_fullStr Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title_full_unstemmed Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title_short Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy
title_sort status of lactate dehydrogenase, neutrophil-lymphocyte ratio, mean platelet volume, and platelet-lymphocyte ratio in bell’s palsy
topic Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186107/
https://www.ncbi.nlm.nih.gov/pubmed/32351812
http://dx.doi.org/10.7759/cureus.7432
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