Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology

Background: Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cir...

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Autores principales: Wang, Yijin, Liu, Hongyang, Jiang, Yiyun, Pan, Qiuwei, Zhao, Jingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186119/
https://www.ncbi.nlm.nih.gov/pubmed/32355864
http://dx.doi.org/10.1093/ofid/ofaa107
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author Wang, Yijin
Liu, Hongyang
Jiang, Yiyun
Pan, Qiuwei
Zhao, Jingmin
author_facet Wang, Yijin
Liu, Hongyang
Jiang, Yiyun
Pan, Qiuwei
Zhao, Jingmin
author_sort Wang, Yijin
collection PubMed
description Background: Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cirrhotic CLD can cause a worsen outcome, leading to exacerbation of AHE, compared with HEV-infected patients without CLD or with noncirrhotic CLD. Additional analysis revealed that the etiology of CLD is not associated with outcomes of AHE patients. These finding suggests that the overall liver status plays a predominant role in determining the outcomes of AHE.
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spelling pubmed-71861192020-04-30 Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology Wang, Yijin Liu, Hongyang Jiang, Yiyun Pan, Qiuwei Zhao, Jingmin Open Forum Infect Dis Brief Report Background: Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cirrhotic CLD can cause a worsen outcome, leading to exacerbation of AHE, compared with HEV-infected patients without CLD or with noncirrhotic CLD. Additional analysis revealed that the etiology of CLD is not associated with outcomes of AHE patients. These finding suggests that the overall liver status plays a predominant role in determining the outcomes of AHE. Oxford University Press 2020-03-26 /pmc/articles/PMC7186119/ /pubmed/32355864 http://dx.doi.org/10.1093/ofid/ofaa107 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Wang, Yijin
Liu, Hongyang
Jiang, Yiyun
Pan, Qiuwei
Zhao, Jingmin
Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title_full Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title_fullStr Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title_full_unstemmed Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title_short Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology
title_sort poor outcomes of acute hepatitis e in patients with cirrhotic liver diseases regardless of etiology
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186119/
https://www.ncbi.nlm.nih.gov/pubmed/32355864
http://dx.doi.org/10.1093/ofid/ofaa107
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