Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2–Mediated COVID-19

OBJECTIVE: To explore the transcriptomic differences between patients with hypertrophic cardiomyopathy (HCM) and controls. PATIENTS AND METHODS: RNA was extracted from cardiac tissue flash frozen at therapeutic surgical septal myectomy for 106 patients with HCM and 39 healthy donor hearts. Expressio...

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Detalles Bibliográficos
Autores principales: Bos, J. Martijn, Hebl, Virginia B., Oberg, Ann L., Sun, Zhifu, Herman, Daniel S., Teekakirikul, Polakit, Seidman, Jonathan G., Seidman, Christine E., dos Remedios, Cristobal G., Maleszewski, Joseph J., Schaff, Hartzell V., Dearani, Joseph A., Noseworthy, Peter A., Friedman, Paul A., Ommen, Steve R., Brozovich, Frank V., Ackerman, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mayo Foundation for Medical Education and Research 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186205/
https://www.ncbi.nlm.nih.gov/pubmed/32448590
http://dx.doi.org/10.1016/j.mayocp.2020.04.028

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