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Use and abuse of dietary supplements in persons with diabetes

The dietary supplement industry has estimated sales of over $30 billion in the US and over $100 billion globally. Many consumers believe that dietary supplements are safer and possibly more effective than drugs to treat diabetes. The sheer volume of the literature in this space makes compiling them...

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Autores principales: Hannon, Bridget A., Fairfield, William D., Adams, Bryan, Kyle, Theodore, Crow, Mason, Thomas, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186221/
https://www.ncbi.nlm.nih.gov/pubmed/32341338
http://dx.doi.org/10.1038/s41387-020-0117-6
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author Hannon, Bridget A.
Fairfield, William D.
Adams, Bryan
Kyle, Theodore
Crow, Mason
Thomas, Diana M.
author_facet Hannon, Bridget A.
Fairfield, William D.
Adams, Bryan
Kyle, Theodore
Crow, Mason
Thomas, Diana M.
author_sort Hannon, Bridget A.
collection PubMed
description The dietary supplement industry has estimated sales of over $30 billion in the US and over $100 billion globally. Many consumers believe that dietary supplements are safer and possibly more effective than drugs to treat diabetes. The sheer volume of the literature in this space makes compiling them into one review challenging, so much so that primarily narrative reviews currently exist. By applying the interactive database supplied by the Office of Dietary Supplements at the National Institutes of Health, we identified the top 100 ingredients that appeared most often in dietary supplement products. One-hundred different keyword searches using the ingredient name and the word diabetes were performed using a program developed to automatically scrape PubMed. Each search was retained in a separate Excel spreadsheet, which was then reviewed for inclusion or exclusion. The studies that met the inclusion criteria were evaluated for effect of reducing and controlling diabetes. The PubMed scrape resulted in 6217 studies. For each keyword search only the most recent 100 were retained, which refined the total to 1823 studies. Of these 425 met the screening criteria. The ingredients, fiber, selenium and zinc had the most studies associated with improvement in diabetes. Several popular supplement ingredients (phosphorus, pantothenic acid, calcium, magnesium, glutamine, isoleucine, tyrosine, choline, and creatine monohydrate) did not result in any studies meeting our screening criteria. Our study demonstrates how to automate reviews to filter and collapse literature in content areas that have an enormous volume of studies. The aggregated set of studies suggest there is little clinical evidence for the use of dietary supplements to reduce or control diabetes.
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spelling pubmed-71862212020-04-29 Use and abuse of dietary supplements in persons with diabetes Hannon, Bridget A. Fairfield, William D. Adams, Bryan Kyle, Theodore Crow, Mason Thomas, Diana M. Nutr Diabetes Review Article The dietary supplement industry has estimated sales of over $30 billion in the US and over $100 billion globally. Many consumers believe that dietary supplements are safer and possibly more effective than drugs to treat diabetes. The sheer volume of the literature in this space makes compiling them into one review challenging, so much so that primarily narrative reviews currently exist. By applying the interactive database supplied by the Office of Dietary Supplements at the National Institutes of Health, we identified the top 100 ingredients that appeared most often in dietary supplement products. One-hundred different keyword searches using the ingredient name and the word diabetes were performed using a program developed to automatically scrape PubMed. Each search was retained in a separate Excel spreadsheet, which was then reviewed for inclusion or exclusion. The studies that met the inclusion criteria were evaluated for effect of reducing and controlling diabetes. The PubMed scrape resulted in 6217 studies. For each keyword search only the most recent 100 were retained, which refined the total to 1823 studies. Of these 425 met the screening criteria. The ingredients, fiber, selenium and zinc had the most studies associated with improvement in diabetes. Several popular supplement ingredients (phosphorus, pantothenic acid, calcium, magnesium, glutamine, isoleucine, tyrosine, choline, and creatine monohydrate) did not result in any studies meeting our screening criteria. Our study demonstrates how to automate reviews to filter and collapse literature in content areas that have an enormous volume of studies. The aggregated set of studies suggest there is little clinical evidence for the use of dietary supplements to reduce or control diabetes. Nature Publishing Group UK 2020-04-27 /pmc/articles/PMC7186221/ /pubmed/32341338 http://dx.doi.org/10.1038/s41387-020-0117-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Hannon, Bridget A.
Fairfield, William D.
Adams, Bryan
Kyle, Theodore
Crow, Mason
Thomas, Diana M.
Use and abuse of dietary supplements in persons with diabetes
title Use and abuse of dietary supplements in persons with diabetes
title_full Use and abuse of dietary supplements in persons with diabetes
title_fullStr Use and abuse of dietary supplements in persons with diabetes
title_full_unstemmed Use and abuse of dietary supplements in persons with diabetes
title_short Use and abuse of dietary supplements in persons with diabetes
title_sort use and abuse of dietary supplements in persons with diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186221/
https://www.ncbi.nlm.nih.gov/pubmed/32341338
http://dx.doi.org/10.1038/s41387-020-0117-6
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