Chidamide epigenetically represses autophagy and exerts cooperative antimyeloma activity with bortezomib

Autophagy and ubiquitin proteasome system are two distinct and cooperative proteolytic pathways. The dual-pathway suppression represents a promising therapeutic strategy for multiple myeloma. Chidamide is a novel benzamide inhibitor of histone deacetylase, and shows potent antimyeloma activity. Here...

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Detalles Bibliográficos
Autores principales: Xu, Li, Feng, Juan, Tang, Hailong, Dong, Ying, Shu, Mimi, Chen, Xiequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186232/
https://www.ncbi.nlm.nih.gov/pubmed/32341332
http://dx.doi.org/10.1038/s41419-020-2414-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186232/
https://www.ncbi.nlm.nih.gov/pubmed/32341332
http://dx.doi.org/10.1038/s41419-020-2414-3

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