Cargando…
Chidamide epigenetically represses autophagy and exerts cooperative antimyeloma activity with bortezomib
Autophagy and ubiquitin proteasome system are two distinct and cooperative proteolytic pathways. The dual-pathway suppression represents a promising therapeutic strategy for multiple myeloma. Chidamide is a novel benzamide inhibitor of histone deacetylase, and shows potent antimyeloma activity. Here...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186232/ https://www.ncbi.nlm.nih.gov/pubmed/32341332 http://dx.doi.org/10.1038/s41419-020-2414-3 |