Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection

Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung a...

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Autores principales: Kong, Qi, Xiang, Zhiguang, Wu, Yue, Gu, Yu, Guo, Jianguo, Geng, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186321/
https://www.ncbi.nlm.nih.gov/pubmed/32345328
http://dx.doi.org/10.1186/s12943-020-01209-2
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author Kong, Qi
Xiang, Zhiguang
Wu, Yue
Gu, Yu
Guo, Jianguo
Geng, Fei
author_facet Kong, Qi
Xiang, Zhiguang
Wu, Yue
Gu, Yu
Guo, Jianguo
Geng, Fei
author_sort Kong, Qi
collection PubMed
description Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
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spelling pubmed-71863212020-04-28 Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection Kong, Qi Xiang, Zhiguang Wu, Yue Gu, Yu Guo, Jianguo Geng, Fei Mol Cancer Letter to the Editor Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels. BioMed Central 2020-04-28 /pmc/articles/PMC7186321/ /pubmed/32345328 http://dx.doi.org/10.1186/s12943-020-01209-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Kong, Qi
Xiang, Zhiguang
Wu, Yue
Gu, Yu
Guo, Jianguo
Geng, Fei
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title_full Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title_fullStr Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title_full_unstemmed Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title_short Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
title_sort analysis of the susceptibility of lung cancer patients to sars-cov-2 infection
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186321/
https://www.ncbi.nlm.nih.gov/pubmed/32345328
http://dx.doi.org/10.1186/s12943-020-01209-2
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