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Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production

Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD...

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Autores principales: Moura, Carla, Trindade, Daniela, Vieira, Milena, Francisco, Luís, Ângelo, David Faustino, Alves, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186357/
https://www.ncbi.nlm.nih.gov/pubmed/32373604
http://dx.doi.org/10.3389/fbioe.2020.00342
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author Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
author_facet Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
author_sort Moura, Carla
collection PubMed
description Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(ε-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multi-material approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds’ porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 μm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 μm filaments are the ones with a closer modulus to the native disc and their properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution.
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spelling pubmed-71863572020-05-05 Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production Moura, Carla Trindade, Daniela Vieira, Milena Francisco, Luís Ângelo, David Faustino Alves, Nuno Front Bioeng Biotechnol Bioengineering and Biotechnology Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(ε-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multi-material approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds’ porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 μm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 μm filaments are the ones with a closer modulus to the native disc and their properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186357/ /pubmed/32373604 http://dx.doi.org/10.3389/fbioe.2020.00342 Text en Copyright © 2020 Moura, Trindade, Vieira, Francisco, Ângelo and Alves. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title_full Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title_fullStr Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title_full_unstemmed Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title_short Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production
title_sort multi-material implants for temporomandibular joint disc repair: tailored additive manufacturing production
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186357/
https://www.ncbi.nlm.nih.gov/pubmed/32373604
http://dx.doi.org/10.3389/fbioe.2020.00342
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