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Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to an inadequate, and heterogeneous vascular network. It is associated with resistance to radiotherapy and results in a poorer clinical outcome. The presence of hypoxia in tumors can be identified by various inv...

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Autores principales: Sørensen, Brita Singers, Horsman, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186437/
https://www.ncbi.nlm.nih.gov/pubmed/32373534
http://dx.doi.org/10.3389/fonc.2020.00562
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author Sørensen, Brita Singers
Horsman, Michael R.
author_facet Sørensen, Brita Singers
Horsman, Michael R.
author_sort Sørensen, Brita Singers
collection PubMed
description Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to an inadequate, and heterogeneous vascular network. It is associated with resistance to radiotherapy and results in a poorer clinical outcome. The presence of hypoxia in tumors can be identified by various invasive and non-invasive techniques, and there are a number of approaches by which hypoxia can be modified to improve outcome. However, despite these factors and the ongoing extensive pre-clinical studies, the clinical focus on hypoxia is still to a large extent lacking. Hypoxia is a major cellular stress factor and affects a wide range of molecular pathways, and further understanding of the molecular processes involved may lead to greater clinical applicability of hypoxic modifiers. This review is a discussion of the characteristics of tumor hypoxia, hypoxia-related molecular pathways, and the role of hypoxia in treatment resistance. Understanding the molecular aspects of hypoxia will improve our ability to clinically monitor hypoxia and to predict and modify the therapeutic response.
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spelling pubmed-71864372020-05-05 Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways Sørensen, Brita Singers Horsman, Michael R. Front Oncol Oncology Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to an inadequate, and heterogeneous vascular network. It is associated with resistance to radiotherapy and results in a poorer clinical outcome. The presence of hypoxia in tumors can be identified by various invasive and non-invasive techniques, and there are a number of approaches by which hypoxia can be modified to improve outcome. However, despite these factors and the ongoing extensive pre-clinical studies, the clinical focus on hypoxia is still to a large extent lacking. Hypoxia is a major cellular stress factor and affects a wide range of molecular pathways, and further understanding of the molecular processes involved may lead to greater clinical applicability of hypoxic modifiers. This review is a discussion of the characteristics of tumor hypoxia, hypoxia-related molecular pathways, and the role of hypoxia in treatment resistance. Understanding the molecular aspects of hypoxia will improve our ability to clinically monitor hypoxia and to predict and modify the therapeutic response. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186437/ /pubmed/32373534 http://dx.doi.org/10.3389/fonc.2020.00562 Text en Copyright © 2020 Sørensen and Horsman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sørensen, Brita Singers
Horsman, Michael R.
Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title_full Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title_fullStr Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title_full_unstemmed Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title_short Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
title_sort tumor hypoxia: impact on radiation therapy and molecular pathways
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186437/
https://www.ncbi.nlm.nih.gov/pubmed/32373534
http://dx.doi.org/10.3389/fonc.2020.00562
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