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Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation

Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disea...

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Autores principales: Kurteva, Elena, Bamford, Alasdair, Cross, Kate, Watson, Tom, Owens, Catherine, Cheng, Fanlek, Hartley, John, Harris, Kathryn, Johnson, Elizabeth M., Lindley, Keith, Levine, Samantha, Köglmeier, Jutta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186448/
https://www.ncbi.nlm.nih.gov/pubmed/32373558
http://dx.doi.org/10.3389/fped.2020.00142
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author Kurteva, Elena
Bamford, Alasdair
Cross, Kate
Watson, Tom
Owens, Catherine
Cheng, Fanlek
Hartley, John
Harris, Kathryn
Johnson, Elizabeth M.
Lindley, Keith
Levine, Samantha
Köglmeier, Jutta
author_facet Kurteva, Elena
Bamford, Alasdair
Cross, Kate
Watson, Tom
Owens, Catherine
Cheng, Fanlek
Hartley, John
Harris, Kathryn
Johnson, Elizabeth M.
Lindley, Keith
Levine, Samantha
Köglmeier, Jutta
author_sort Kurteva, Elena
collection PubMed
description Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of Basidiobolus. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication.
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spelling pubmed-71864482020-05-05 Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation Kurteva, Elena Bamford, Alasdair Cross, Kate Watson, Tom Owens, Catherine Cheng, Fanlek Hartley, John Harris, Kathryn Johnson, Elizabeth M. Lindley, Keith Levine, Samantha Köglmeier, Jutta Front Pediatr Pediatrics Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of Basidiobolus. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186448/ /pubmed/32373558 http://dx.doi.org/10.3389/fped.2020.00142 Text en Copyright © 2020 Kurteva, Bamford, Cross, Watson, Owens, Cheng, Hartley, Harris, Johnson, Lindley, Levine and Köglmeier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kurteva, Elena
Bamford, Alasdair
Cross, Kate
Watson, Tom
Owens, Catherine
Cheng, Fanlek
Hartley, John
Harris, Kathryn
Johnson, Elizabeth M.
Lindley, Keith
Levine, Samantha
Köglmeier, Jutta
Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title_full Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title_fullStr Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title_full_unstemmed Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title_short Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
title_sort colonic basidiobolomycosis—an unusual presentation of eosinophilic intestinal inflammation
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186448/
https://www.ncbi.nlm.nih.gov/pubmed/32373558
http://dx.doi.org/10.3389/fped.2020.00142
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