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Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disea...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186448/ https://www.ncbi.nlm.nih.gov/pubmed/32373558 http://dx.doi.org/10.3389/fped.2020.00142 |
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author | Kurteva, Elena Bamford, Alasdair Cross, Kate Watson, Tom Owens, Catherine Cheng, Fanlek Hartley, John Harris, Kathryn Johnson, Elizabeth M. Lindley, Keith Levine, Samantha Köglmeier, Jutta |
author_facet | Kurteva, Elena Bamford, Alasdair Cross, Kate Watson, Tom Owens, Catherine Cheng, Fanlek Hartley, John Harris, Kathryn Johnson, Elizabeth M. Lindley, Keith Levine, Samantha Köglmeier, Jutta |
author_sort | Kurteva, Elena |
collection | PubMed |
description | Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of Basidiobolus. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication. |
format | Online Article Text |
id | pubmed-7186448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71864482020-05-05 Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation Kurteva, Elena Bamford, Alasdair Cross, Kate Watson, Tom Owens, Catherine Cheng, Fanlek Hartley, John Harris, Kathryn Johnson, Elizabeth M. Lindley, Keith Levine, Samantha Köglmeier, Jutta Front Pediatr Pediatrics Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of Basidiobolus. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186448/ /pubmed/32373558 http://dx.doi.org/10.3389/fped.2020.00142 Text en Copyright © 2020 Kurteva, Bamford, Cross, Watson, Owens, Cheng, Hartley, Harris, Johnson, Lindley, Levine and Köglmeier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Kurteva, Elena Bamford, Alasdair Cross, Kate Watson, Tom Owens, Catherine Cheng, Fanlek Hartley, John Harris, Kathryn Johnson, Elizabeth M. Lindley, Keith Levine, Samantha Köglmeier, Jutta Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title | Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title_full | Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title_fullStr | Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title_full_unstemmed | Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title_short | Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation |
title_sort | colonic basidiobolomycosis—an unusual presentation of eosinophilic intestinal inflammation |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186448/ https://www.ncbi.nlm.nih.gov/pubmed/32373558 http://dx.doi.org/10.3389/fped.2020.00142 |
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