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Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic thir...

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Autores principales: Stein, Marco, Dohmen, Hildegard, Wölk, Bernhard, Eberle, Fabian, Kolodziej, Malgorzata, Acker, Till, Uhl, Eberhard, Jensen, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186451/
https://www.ncbi.nlm.nih.gov/pubmed/32373516
http://dx.doi.org/10.3389/fonc.2020.00477
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author Stein, Marco
Dohmen, Hildegard
Wölk, Bernhard
Eberle, Fabian
Kolodziej, Malgorzata
Acker, Till
Uhl, Eberhard
Jensen, Alexandra
author_facet Stein, Marco
Dohmen, Hildegard
Wölk, Bernhard
Eberle, Fabian
Kolodziej, Malgorzata
Acker, Till
Uhl, Eberhard
Jensen, Alexandra
author_sort Stein, Marco
collection PubMed
description Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the histopathologic diagnosis of a malignant glioma was confirmed by DNA methylation array as GBM isocitrate dehydrogenase wild type. The patient was treated with combined treatment of chemoradiation with temozolomide (TMZ) including proton boost, TMZ maintenance, and tumor-treating fields. In this case report, complete radiological response was observed 1 year after the end of radiation therapy.
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spelling pubmed-71864512020-05-05 Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields Stein, Marco Dohmen, Hildegard Wölk, Bernhard Eberle, Fabian Kolodziej, Malgorzata Acker, Till Uhl, Eberhard Jensen, Alexandra Front Oncol Oncology Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the histopathologic diagnosis of a malignant glioma was confirmed by DNA methylation array as GBM isocitrate dehydrogenase wild type. The patient was treated with combined treatment of chemoradiation with temozolomide (TMZ) including proton boost, TMZ maintenance, and tumor-treating fields. In this case report, complete radiological response was observed 1 year after the end of radiation therapy. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186451/ /pubmed/32373516 http://dx.doi.org/10.3389/fonc.2020.00477 Text en Copyright © 2020 Stein, Dohmen, Wölk, Eberle, Kolodziej, Acker, Uhl and Jensen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Stein, Marco
Dohmen, Hildegard
Wölk, Bernhard
Eberle, Fabian
Kolodziej, Malgorzata
Acker, Till
Uhl, Eberhard
Jensen, Alexandra
Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title_full Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title_fullStr Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title_full_unstemmed Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title_short Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
title_sort case report of complete radiological response of a thalamic glioblastoma after treatment with proton therapy followed by temozolomide and tumor-treating fields
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186451/
https://www.ncbi.nlm.nih.gov/pubmed/32373516
http://dx.doi.org/10.3389/fonc.2020.00477
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