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Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic thir...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186451/ https://www.ncbi.nlm.nih.gov/pubmed/32373516 http://dx.doi.org/10.3389/fonc.2020.00477 |
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author | Stein, Marco Dohmen, Hildegard Wölk, Bernhard Eberle, Fabian Kolodziej, Malgorzata Acker, Till Uhl, Eberhard Jensen, Alexandra |
author_facet | Stein, Marco Dohmen, Hildegard Wölk, Bernhard Eberle, Fabian Kolodziej, Malgorzata Acker, Till Uhl, Eberhard Jensen, Alexandra |
author_sort | Stein, Marco |
collection | PubMed |
description | Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the histopathologic diagnosis of a malignant glioma was confirmed by DNA methylation array as GBM isocitrate dehydrogenase wild type. The patient was treated with combined treatment of chemoradiation with temozolomide (TMZ) including proton boost, TMZ maintenance, and tumor-treating fields. In this case report, complete radiological response was observed 1 year after the end of radiation therapy. |
format | Online Article Text |
id | pubmed-7186451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71864512020-05-05 Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields Stein, Marco Dohmen, Hildegard Wölk, Bernhard Eberle, Fabian Kolodziej, Malgorzata Acker, Till Uhl, Eberhard Jensen, Alexandra Front Oncol Oncology Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. We present a case of a 42-year-old male patient presenting with headache and vomiting. Imaging demonstrated obstructive hydrocephalus and a ring-enhancing lesion in the right posterior thalamus. After endoscopic third ventriculostomy and stereotactic biopsy, the histopathologic diagnosis of a malignant glioma was confirmed by DNA methylation array as GBM isocitrate dehydrogenase wild type. The patient was treated with combined treatment of chemoradiation with temozolomide (TMZ) including proton boost, TMZ maintenance, and tumor-treating fields. In this case report, complete radiological response was observed 1 year after the end of radiation therapy. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186451/ /pubmed/32373516 http://dx.doi.org/10.3389/fonc.2020.00477 Text en Copyright © 2020 Stein, Dohmen, Wölk, Eberle, Kolodziej, Acker, Uhl and Jensen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Stein, Marco Dohmen, Hildegard Wölk, Bernhard Eberle, Fabian Kolodziej, Malgorzata Acker, Till Uhl, Eberhard Jensen, Alexandra Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title | Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title_full | Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title_fullStr | Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title_full_unstemmed | Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title_short | Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields |
title_sort | case report of complete radiological response of a thalamic glioblastoma after treatment with proton therapy followed by temozolomide and tumor-treating fields |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186451/ https://www.ncbi.nlm.nih.gov/pubmed/32373516 http://dx.doi.org/10.3389/fonc.2020.00477 |
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