Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143

Overexpression of the PbrlaeA gene of the fungus Penicillium brocae HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (1), whose configuration has not been reported before, and one new compound iso-fumigatin chlorohydrin (2). All structures including absolute co...

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Autores principales: Wang, Lu, Zhang, Xianyan, Zhang, Kaijin, Zhang, Xiaomin, Zhu, Tianjiao, Che, Qian, Zhang, Guojian, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186497/
https://www.ncbi.nlm.nih.gov/pubmed/32373583
http://dx.doi.org/10.3389/fchem.2020.00270
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author Wang, Lu
Zhang, Xianyan
Zhang, Kaijin
Zhang, Xiaomin
Zhu, Tianjiao
Che, Qian
Zhang, Guojian
Li, Dehai
author_facet Wang, Lu
Zhang, Xianyan
Zhang, Kaijin
Zhang, Xiaomin
Zhu, Tianjiao
Che, Qian
Zhang, Guojian
Li, Dehai
author_sort Wang, Lu
collection PubMed
description Overexpression of the PbrlaeA gene of the fungus Penicillium brocae HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (1), whose configuration has not been reported before, and one new compound iso-fumigatin chlorohydrin (2). All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data, (13)C NMR calculations, and ECD calculations. Compounds 1 and 2 exhibited cytotoxic activity against HL-60 with IC(50) of 18.63 and 24.83 μM.
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spelling pubmed-71864972020-05-05 Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143 Wang, Lu Zhang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhu, Tianjiao Che, Qian Zhang, Guojian Li, Dehai Front Chem Chemistry Overexpression of the PbrlaeA gene of the fungus Penicillium brocae HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (1), whose configuration has not been reported before, and one new compound iso-fumigatin chlorohydrin (2). All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data, (13)C NMR calculations, and ECD calculations. Compounds 1 and 2 exhibited cytotoxic activity against HL-60 with IC(50) of 18.63 and 24.83 μM. Frontiers Media S.A. 2020-04-21 /pmc/articles/PMC7186497/ /pubmed/32373583 http://dx.doi.org/10.3389/fchem.2020.00270 Text en Copyright © 2020 Wang, Zhang, Zhang, Zhang, Zhu, Che, Zhang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Lu
Zhang, Xianyan
Zhang, Kaijin
Zhang, Xiaomin
Zhu, Tianjiao
Che, Qian
Zhang, Guojian
Li, Dehai
Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title_full Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title_fullStr Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title_full_unstemmed Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title_short Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143
title_sort overexpression of global regulator pbrlaea leads to the discovery of new polyketide in fungus penicillium brocae hdn-12-143
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186497/
https://www.ncbi.nlm.nih.gov/pubmed/32373583
http://dx.doi.org/10.3389/fchem.2020.00270
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