Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

BACKGROUND: The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to determine whether the BA pathway is altered and correctable in human obesity and diabetes. METHODS: We conducted 3 investigations: 1) BA...

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Detalles Bibliográficos
Autores principales: Calderon, Gerardo, McRae, Alison, Rievaj, Juraj, Davis, Judith, Zandvakili, Inuk, Linker-Nord, Sara, Burton, Duane, Roberts, Geoffrey, Reimann, Frank, Gedulin, Bronislava, Vella, Adrian, LaRusso, Nicholas F, Camilleri, Michael, Gribble, Fiona M, Acosta, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186521/
https://www.ncbi.nlm.nih.gov/pubmed/32344198
http://dx.doi.org/10.1016/j.ebiom.2020.102759

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