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Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

OBJECTIVE: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...

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Detalles Bibliográficos
Autores principales:	Rodríguez-Comas, Júlia, Moreno-Vedia, Juan, Obach, Mercè, Castaño, Carlos, de Pablo, Sara, Alcarraz-Vizán, Gema, Díaz-Catalán, Daniela, Mestre, Anna, Horrillo, Raquel, Costa, Montserrat, Novials, Anna, Servitja, Joan-Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186564/ https://www.ncbi.nlm.nih.gov/pubmed/32229246 http://dx.doi.org/10.1016/j.molmet.2020.100984

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