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AZD3463, an IGF-1R inhibitor, suppresses breast cancer metastasis to bone via modulation of the PI3K-Akt pathway

BACKGROUND: The bone-derived insulin-like growth factor I (IGF-1) and its receptor IGF-1R play a crucial role in promoting the survival and proliferation of cancer cells, and have thus been considered as prime targets for the development of novel antitumor therapeutics. METHODS: By using the MDA-MB-...

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Detalles Bibliográficos
Autores principales:	Hu, Guang-Fu, Wang, Cheng, Hu, Guang-Xia, Wu, Ge, Zhang, Chengjiao, Zhu, Wei, Chen, Cong, Gu, Yutong, Zhang, Hongwei, Yang, Zi’ang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186597/ https://www.ncbi.nlm.nih.gov/pubmed/32355780 http://dx.doi.org/10.21037/atm.2020.02.110

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