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Infection prophylaxis and management of viral infection
Viral infections are associated with significant morbidity and mortality in lung transplant recipients. Importantly, several viral infections have been associated with the development of chronic lung allograft dysfunction (CLAD). Community-acquired respiratory viruses (CARV) such as influenza and re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186616/ https://www.ncbi.nlm.nih.gov/pubmed/32355859 http://dx.doi.org/10.21037/atm.2019.11.85 |
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author | Clausen, Emily S. Zaffiri, Lorenzo |
author_facet | Clausen, Emily S. Zaffiri, Lorenzo |
author_sort | Clausen, Emily S. |
collection | PubMed |
description | Viral infections are associated with significant morbidity and mortality in lung transplant recipients. Importantly, several viral infections have been associated with the development of chronic lung allograft dysfunction (CLAD). Community-acquired respiratory viruses (CARV) such as influenza and respiratory syncytial virus (RSV), are frequently associated with acute and chronic rejection. Cytomegalovirus (CMV) remains a significant burden in regards to morbidity and mortality in lung transplant recipients. Epstein-Barr virus (EBV) is mostly involved with the development of post-transplant lymphoproliferative disorder (PTLD), a lymphoid proliferation that occurs in the setting of immunosuppression. On the other hand, the development of direct acting antivirals for hepatitis C virus (HCV) is changing the use of HCV-positive organs in transplantation. In this article we will focus on reviewing common viral infections that have a significant impact on lung transplant recipients looking at epidemiology, prevention and potential treatment. |
format | Online Article Text |
id | pubmed-7186616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-71866162020-04-30 Infection prophylaxis and management of viral infection Clausen, Emily S. Zaffiri, Lorenzo Ann Transl Med Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation Viral infections are associated with significant morbidity and mortality in lung transplant recipients. Importantly, several viral infections have been associated with the development of chronic lung allograft dysfunction (CLAD). Community-acquired respiratory viruses (CARV) such as influenza and respiratory syncytial virus (RSV), are frequently associated with acute and chronic rejection. Cytomegalovirus (CMV) remains a significant burden in regards to morbidity and mortality in lung transplant recipients. Epstein-Barr virus (EBV) is mostly involved with the development of post-transplant lymphoproliferative disorder (PTLD), a lymphoid proliferation that occurs in the setting of immunosuppression. On the other hand, the development of direct acting antivirals for hepatitis C virus (HCV) is changing the use of HCV-positive organs in transplantation. In this article we will focus on reviewing common viral infections that have a significant impact on lung transplant recipients looking at epidemiology, prevention and potential treatment. AME Publishing Company 2020-03 /pmc/articles/PMC7186616/ /pubmed/32355859 http://dx.doi.org/10.21037/atm.2019.11.85 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation Clausen, Emily S. Zaffiri, Lorenzo Infection prophylaxis and management of viral infection |
title | Infection prophylaxis and management of viral infection |
title_full | Infection prophylaxis and management of viral infection |
title_fullStr | Infection prophylaxis and management of viral infection |
title_full_unstemmed | Infection prophylaxis and management of viral infection |
title_short | Infection prophylaxis and management of viral infection |
title_sort | infection prophylaxis and management of viral infection |
topic | Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186616/ https://www.ncbi.nlm.nih.gov/pubmed/32355859 http://dx.doi.org/10.21037/atm.2019.11.85 |
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