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Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis

BACKGROUND: Colon adenocarcinoma (COAD) is one of the most commonly diagnosed cancers, and it is closely related to the immune microenvironment. Considering that immunotherapy is not effective for all COAD patients, it is necessary to identify the effective population before administering treatment....

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Autores principales: Qiang, Weijie, Dai, Yifei, Sun, Guibo, Xing, Xiaoyan, Sun, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186653/
https://www.ncbi.nlm.nih.gov/pubmed/32355728
http://dx.doi.org/10.21037/atm.2020.03.09
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author Qiang, Weijie
Dai, Yifei
Sun, Guibo
Xing, Xiaoyan
Sun, Xiaobo
author_facet Qiang, Weijie
Dai, Yifei
Sun, Guibo
Xing, Xiaoyan
Sun, Xiaobo
author_sort Qiang, Weijie
collection PubMed
description BACKGROUND: Colon adenocarcinoma (COAD) is one of the most commonly diagnosed cancers, and it is closely related to the immune microenvironment. Considering that immunotherapy is not effective for all COAD patients, it is necessary to identify the effective population before administering treatment. In this study, we established an independent prognostic index based on immune-related genes (IRGs), in order to evaluate the clinical outcome of COAD. METHODS: The gene expression profiles and IRGs taken from The Cancer Genome Atlas (TCGA) and Immunology Database and Analysis Portal (ImmPort), respectively, were integrated in order to identify the differentially expressed IRGs. Functional enrichment analysis was conducted and the prognostic value of survival-related IRGs was determined. Based on Cox regression analysis, the IRG-based prognostic index (IRGPI) was established, and the model was evaluated and applied. RESULTS: A total of 51 differentially expressed survival-related IRGs were identified. The most significant signaling pathway was “cytokine-cytokine receptor interaction”. The index established herein was based on 12 survival-related IRGs, and it was highly accurate in monitoring prognosis. Moreover, the IRGPI was significantly correlated with multiple clinicopathologic factors, as well as with the infiltration of immune cells. CONCLUSIONS: An independent IRGPI was established in order to assess the immune status and tumor prognosis in COAD patients. This index can serve as a robust biomarker in clinical prognosis applications, including cancer immunotherapy.
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spelling pubmed-71866532020-04-30 Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis Qiang, Weijie Dai, Yifei Sun, Guibo Xing, Xiaoyan Sun, Xiaobo Ann Transl Med Original Article BACKGROUND: Colon adenocarcinoma (COAD) is one of the most commonly diagnosed cancers, and it is closely related to the immune microenvironment. Considering that immunotherapy is not effective for all COAD patients, it is necessary to identify the effective population before administering treatment. In this study, we established an independent prognostic index based on immune-related genes (IRGs), in order to evaluate the clinical outcome of COAD. METHODS: The gene expression profiles and IRGs taken from The Cancer Genome Atlas (TCGA) and Immunology Database and Analysis Portal (ImmPort), respectively, were integrated in order to identify the differentially expressed IRGs. Functional enrichment analysis was conducted and the prognostic value of survival-related IRGs was determined. Based on Cox regression analysis, the IRG-based prognostic index (IRGPI) was established, and the model was evaluated and applied. RESULTS: A total of 51 differentially expressed survival-related IRGs were identified. The most significant signaling pathway was “cytokine-cytokine receptor interaction”. The index established herein was based on 12 survival-related IRGs, and it was highly accurate in monitoring prognosis. Moreover, the IRGPI was significantly correlated with multiple clinicopathologic factors, as well as with the infiltration of immune cells. CONCLUSIONS: An independent IRGPI was established in order to assess the immune status and tumor prognosis in COAD patients. This index can serve as a robust biomarker in clinical prognosis applications, including cancer immunotherapy. AME Publishing Company 2020-03 /pmc/articles/PMC7186653/ /pubmed/32355728 http://dx.doi.org/10.21037/atm.2020.03.09 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Qiang, Weijie
Dai, Yifei
Sun, Guibo
Xing, Xiaoyan
Sun, Xiaobo
Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title_full Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title_fullStr Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title_full_unstemmed Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title_short Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
title_sort development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186653/
https://www.ncbi.nlm.nih.gov/pubmed/32355728
http://dx.doi.org/10.21037/atm.2020.03.09
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