Cargando…

Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment

A large number of immune cells are present in the tumour microenvironment (TME), of which, tumour-associated macrophages (TAMs) are among the most important and highly infiltrated cells, and mainly include the M1 type classically activated and M2 type alternatively activated TAMs. Both cell types ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Wenjie, Yang, Shikun, Zhang, Feng, Cheng, Feng, Wang, Xuehao, Rao, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186717/
https://www.ncbi.nlm.nih.gov/pubmed/32355843
http://dx.doi.org/10.21037/atm.2020.02.11
_version_ 1783527012766318592
author Yang, Wenjie
Yang, Shikun
Zhang, Feng
Cheng, Feng
Wang, Xuehao
Rao, Jianhua
author_facet Yang, Wenjie
Yang, Shikun
Zhang, Feng
Cheng, Feng
Wang, Xuehao
Rao, Jianhua
author_sort Yang, Wenjie
collection PubMed
description A large number of immune cells are present in the tumour microenvironment (TME), of which, tumour-associated macrophages (TAMs) are among the most important and highly infiltrated cells, and mainly include the M1 type classically activated and M2 type alternatively activated TAMs. Both cell types are known to play an important role in tumour initiation and proliferation. It has recently been confirmed that the TAMs in tumours tend to be dominated by the M2 type. However, the precise mechanism underlying TAM recruitment and polarization in the immune microenvironment remains to be elucidated. The Hippo-Yes-associated protein (YAP) signalling pathway is one of the most extensively discussed mechanism for the regulation of tumour proliferation, migration, angiogenesis, and invasion in recent years. To date, several studies have revealed that YAP is involved in the interrelating interactions between tumour and immune cells, particularly the TAMs. In this review, we have summarized the mechanism by which the YAP regulates the activity of TAMs and its impact on the TME.
format Online
Article
Text
id pubmed-7186717
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-71867172020-04-30 Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment Yang, Wenjie Yang, Shikun Zhang, Feng Cheng, Feng Wang, Xuehao Rao, Jianhua Ann Transl Med Review Article A large number of immune cells are present in the tumour microenvironment (TME), of which, tumour-associated macrophages (TAMs) are among the most important and highly infiltrated cells, and mainly include the M1 type classically activated and M2 type alternatively activated TAMs. Both cell types are known to play an important role in tumour initiation and proliferation. It has recently been confirmed that the TAMs in tumours tend to be dominated by the M2 type. However, the precise mechanism underlying TAM recruitment and polarization in the immune microenvironment remains to be elucidated. The Hippo-Yes-associated protein (YAP) signalling pathway is one of the most extensively discussed mechanism for the regulation of tumour proliferation, migration, angiogenesis, and invasion in recent years. To date, several studies have revealed that YAP is involved in the interrelating interactions between tumour and immune cells, particularly the TAMs. In this review, we have summarized the mechanism by which the YAP regulates the activity of TAMs and its impact on the TME. AME Publishing Company 2020-03 /pmc/articles/PMC7186717/ /pubmed/32355843 http://dx.doi.org/10.21037/atm.2020.02.11 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
Yang, Wenjie
Yang, Shikun
Zhang, Feng
Cheng, Feng
Wang, Xuehao
Rao, Jianhua
Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title_full Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title_fullStr Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title_full_unstemmed Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title_short Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
title_sort influence of the hippo-yap signalling pathway on tumor associated macrophages (tams) and its implications on cancer immunosuppressive microenvironment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186717/
https://www.ncbi.nlm.nih.gov/pubmed/32355843
http://dx.doi.org/10.21037/atm.2020.02.11
work_keys_str_mv AT yangwenjie influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment
AT yangshikun influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment
AT zhangfeng influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment
AT chengfeng influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment
AT wangxuehao influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment
AT raojianhua influenceofthehippoyapsignallingpathwayontumorassociatedmacrophagestamsanditsimplicationsoncancerimmunosuppressivemicroenvironment