An update on chronic lung allograft dysfunction

Chronic lung allograft dysfunction (CLAD) remains a significant challenge and the major determinant of morbidity and mortality post lung transplantation (LTx). The definition of CLAD has evolved significantly over the last ten years, reflecting better understanding of pathophysiology and different p...

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Autores principales: Kotecha, Sakhee, Paraskeva, Miranda A., Levin, Kovi, Snell, Gregory I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186740/
https://www.ncbi.nlm.nih.gov/pubmed/32355861
http://dx.doi.org/10.21037/atm.2020.01.05
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author Kotecha, Sakhee
Paraskeva, Miranda A.
Levin, Kovi
Snell, Gregory I.
author_facet Kotecha, Sakhee
Paraskeva, Miranda A.
Levin, Kovi
Snell, Gregory I.
author_sort Kotecha, Sakhee
collection PubMed
description Chronic lung allograft dysfunction (CLAD) remains a significant challenge and the major determinant of morbidity and mortality post lung transplantation (LTx). The definition of CLAD has evolved significantly over the last ten years, reflecting better understanding of pathophysiology and different phenotypes. While there is an agreed consensus approach to CLAD, questions remain regarding the limitations of lung function parameters as well as the role of imaging and histopathology. Here we present a current snapshot of the definition of CLAD, its evolution and future directions.
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spelling pubmed-71867402020-04-30 An update on chronic lung allograft dysfunction Kotecha, Sakhee Paraskeva, Miranda A. Levin, Kovi Snell, Gregory I. Ann Transl Med Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation Chronic lung allograft dysfunction (CLAD) remains a significant challenge and the major determinant of morbidity and mortality post lung transplantation (LTx). The definition of CLAD has evolved significantly over the last ten years, reflecting better understanding of pathophysiology and different phenotypes. While there is an agreed consensus approach to CLAD, questions remain regarding the limitations of lung function parameters as well as the role of imaging and histopathology. Here we present a current snapshot of the definition of CLAD, its evolution and future directions. AME Publishing Company 2020-03 /pmc/articles/PMC7186740/ /pubmed/32355861 http://dx.doi.org/10.21037/atm.2020.01.05 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation
Kotecha, Sakhee
Paraskeva, Miranda A.
Levin, Kovi
Snell, Gregory I.
An update on chronic lung allograft dysfunction
title An update on chronic lung allograft dysfunction
title_full An update on chronic lung allograft dysfunction
title_fullStr An update on chronic lung allograft dysfunction
title_full_unstemmed An update on chronic lung allograft dysfunction
title_short An update on chronic lung allograft dysfunction
title_sort update on chronic lung allograft dysfunction
topic Review Article on Strategies to Achieve Long-Term Success of Lung Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186740/
https://www.ncbi.nlm.nih.gov/pubmed/32355861
http://dx.doi.org/10.21037/atm.2020.01.05
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