Cargando…

Non-disruptive mutation in TP53 DNA-binding domain is a beneficial factor of esophageal squamous cell carcinoma

BACKGROUND: TP53 is frequently altered in esophageal squamous cell carcinoma (ESCC). However, the landscape of TP53 mutation and its effects on patients remain controversial. METHODS: Somatic mutations of TP53 in 161 patients with resectable ESCC were identified by next-generation sequencing (NGS) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Minran, Jin, Jiaoyue, Zhang, Fanrong, Wu, Yingxue, Xu, Chenyang, Ying, Lisha, Su, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186752/ https://www.ncbi.nlm.nih.gov/pubmed/32355760 http://dx.doi.org/10.21037/atm.2020.02.142

Ejemplares similares

GAP43, a novel metastasis promoter in non-small cell lung cancer
por: Zhang, Fanrong, et al.
Publicado: (2018)

Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma
por: Su, Dan, et al.
Publicado: (2019)

Prognostic significance of programmed death-1 and programmed death-ligand 1 expression in patients with esophageal squamous cell carcinoma
por: Chen, Kaiyan, et al.
Publicado: (2016)

The High Expression of p53 Is Predictive of Poor Survival Rather TP53 Mutation in Esophageal Squamous Cell Carcinoma
por: Jin, Yan, et al.
Publicado: (2023)

Tumor-Infiltrating CD4+ Lymphocytes Predict a Favorable Survival in Patients with Operable Esophageal Squamous Cell Carcinoma
por: Chen, Kaiyan, et al.
Publicado: (2017)

Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor‐κB signaling in esophageal squamous cell carcinoma
por: Wu, Junzhou, et al.
Publicado: (2017)

Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma
por: Lapke, Nina, et al.
Publicado: (2016)

Extremely High Tp53 Mutation Load in Esophageal Squamous Cell Carcinoma in Golestan Province, Iran
por: Abedi-Ardekani, Behnoush, et al.
Publicado: (2011)

Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma
por: Pain, Margaret, et al.
Publicado: (2017)

PRIMA‐1 induces p53‐mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation
por: Furukawa, Haruna, et al.
Publicado: (2017)

Analysis of Tp53 Codon 72 Polymorphisms, Tp53 Mutations, and HPV Infection in Cutaneous Squamous Cell Carcinomas
por: Loeb, Keith R., et al.
Publicado: (2012)

The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma
por: Omura, Go, et al.
Publicado: (2017)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

Oncogenic Alterations in Histologically Negative Lymph Nodes Are Associated with Prognosis of Patients with Stage I Lung Adenocarcinoma
por: Tian, Yiping, et al.
Publicado: (2022)

TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study
por: Catherwood, Mark A., et al.
Publicado: (2022)

HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53
por: Meulendijks, D, et al.
Publicado: (2015)

Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
por: Bellini, Marilanda Ferreira, et al.
Publicado: (2012)

TP53 DNA Binding Domain Mutations Predict Progression-Free Survival of Bevacizumab Therapy in Metastatic Colorectal Cancer
por: Hsu, Hung-Chih, et al.
Publicado: (2019)

TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva
por: Rolfe, K J, et al.
Publicado: (2003)

Studies of TP53 haplotypes in relation to LOH and TP53 mutations in breast cancer patients
por: Langerød, A, et al.
Publicado: (2000)

Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell Cancer
por: Lyu, Haoyu, et al.
Publicado: (2019)

Telomere status in chronic lymphocytic leukemia with TP53 disruption
por: Guièze, Romain, et al.
Publicado: (2016)

Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma
por: Kang, Nan, et al.
Publicado: (2018)

Immune-active tumor-adjacent tissues are associated with favorable prognosis in stage I lung squamous cell carcinoma
por: Ying, Lisha, et al.
Publicado: (2023)

Mutations in Zinc‐binding Domains of p53 as a Prognostic Marker of Esophageal‐cancer Patients
por: Kihara, Chikashi, et al.
Publicado: (2000)

Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA
por: Li, Xuerui, et al.
Publicado: (2020)

Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma()
por: Quaas, Alexander, et al.
Publicado: (2018)

Investigation on the Potential Correlation Between TP53 and Esophageal Cancer
por: Yao, Lihua, et al.
Publicado: (2021)

miR612 is associated with esophageal squamous cell carcinoma development and metastasis, mediated through TP53
por: Zhou, Ping, et al.
Publicado: (2017)

TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes
por: Yabe, Mariko, et al.
Publicado: (2021)

TP53_PROF: a machine learning model to predict impact of missense mutations in TP53
por: Ben-Cohen, Gil, et al.
Publicado: (2022)

KRAS and TP53 Mutations in Colorectal Carcinoma
por: Al-Kuraya, Khawla S.
Publicado: (2009)

TP53 Targeted Deep Sequencing of Cell-Free DNA in Esophageal Squamous Cell Carcinoma Using Low-Quality Serum: Concordance with Tumor Mutation
por: Nasrollahzadeh, Dariush, et al.
Publicado: (2021)

TTN/TP53 mutation might act as the predictor for chemotherapy response in lung adenocarcinoma and lung squamous carcinoma patients
por: Xue, Dan, et al.
Publicado: (2021)

Association between TP53 gene deletion and protein expression in esophageal squamous cell carcinoma and its prognostic significance
por: Niyaz, Madiniyet, et al.
Publicado: (2020)

CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
por: Wang, Hui, et al.
Publicado: (2020)

Prognostic value genotypes and LOH at TP53 codon 72 and TP53 mutations in primary breast cancer
por: Kyndi, M, et al.
Publicado: (2005)

The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes
por: McGraw, K L, et al.
Publicado: (2015)

p53 pathway dysfunction in AML: beyond TP53 mutations
por: Post, Sean M., et al.
Publicado: (2017)

Early TP53 Alterations Shape Gastric and Esophageal Cancer Development
por: Sahgal, Pranshu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j67879eqcrhub6a4gvm4qbj791