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Chemical‐Shift Perturbations Reflect Bile Acid Binding to Norovirus Coat Protein: Recognition Comes in Different Flavors

Bile acids have been reported as important cofactors promoting human and murine norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Through the use of chemical shift perturbation (CSP) NMR experiments, we identified a low‐affinity bile acid binding site of a human...

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Detalles Bibliográficos
Autores principales: Creutznacher, Robert, Schulze, Eric, Wallmann, Georg, Peters, Thomas, Stein, Matthias, Mallagaray, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186840/
https://www.ncbi.nlm.nih.gov/pubmed/31644826
http://dx.doi.org/10.1002/cbic.201900572