Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review

Essential thrombocythaemia (ET) and Waldenström macroglobulinaemia (WM) are two distinct disorders. Studies have reported several cases of myeloproliferative neoplasms (MPNs) with concomitant plasma cell dyscrasia. However, there were no reported cases of ET with concomitant WM to date. Here, we pre...

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Autores principales: Lu, Nina, Neoh, Chin Loon, Ruan, Zhengying, Zhao, Lei, Ying, Limei, Zhang, Xiaochang, Chen, Sai, Xu, Linglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186880/
https://www.ncbi.nlm.nih.gov/pubmed/32425546
http://dx.doi.org/10.2147/OTT.S245950
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author Lu, Nina
Neoh, Chin Loon
Ruan, Zhengying
Zhao, Lei
Ying, Limei
Zhang, Xiaochang
Chen, Sai
Xu, Linglong
author_facet Lu, Nina
Neoh, Chin Loon
Ruan, Zhengying
Zhao, Lei
Ying, Limei
Zhang, Xiaochang
Chen, Sai
Xu, Linglong
author_sort Lu, Nina
collection PubMed
description Essential thrombocythaemia (ET) and Waldenström macroglobulinaemia (WM) are two distinct disorders. Studies have reported several cases of myeloproliferative neoplasms (MPNs) with concomitant plasma cell dyscrasia. However, there were no reported cases of ET with concomitant WM to date. Here, we present a 55-year-old Chinese man with thrombocytosis and raised immunoglobulin level. Further investigations led to a diagnosis of ET and coexistent WM. Next-generation sequencing (NGS) of his bone marrow identified 3 mutated genes: JAK2 V617F, MYD88 L265P, and ATM F1036L. After being treated with pegylated interferon and low-dose aspirin, his platelet count normalized and immunoglobulin M (IgM) level reduced. To the best of our knowledge, this is the first reported case of dual pathology ET with WM.
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spelling pubmed-71868802020-05-18 Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review Lu, Nina Neoh, Chin Loon Ruan, Zhengying Zhao, Lei Ying, Limei Zhang, Xiaochang Chen, Sai Xu, Linglong Onco Targets Ther Case Report Essential thrombocythaemia (ET) and Waldenström macroglobulinaemia (WM) are two distinct disorders. Studies have reported several cases of myeloproliferative neoplasms (MPNs) with concomitant plasma cell dyscrasia. However, there were no reported cases of ET with concomitant WM to date. Here, we present a 55-year-old Chinese man with thrombocytosis and raised immunoglobulin level. Further investigations led to a diagnosis of ET and coexistent WM. Next-generation sequencing (NGS) of his bone marrow identified 3 mutated genes: JAK2 V617F, MYD88 L265P, and ATM F1036L. After being treated with pegylated interferon and low-dose aspirin, his platelet count normalized and immunoglobulin M (IgM) level reduced. To the best of our knowledge, this is the first reported case of dual pathology ET with WM. Dove 2020-04-23 /pmc/articles/PMC7186880/ /pubmed/32425546 http://dx.doi.org/10.2147/OTT.S245950 Text en © 2020 Lu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Lu, Nina
Neoh, Chin Loon
Ruan, Zhengying
Zhao, Lei
Ying, Limei
Zhang, Xiaochang
Chen, Sai
Xu, Linglong
Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title_full Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title_fullStr Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title_full_unstemmed Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title_short Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review
title_sort essential thrombocythaemia with concomitant waldenström macroglobulinaemia: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186880/
https://www.ncbi.nlm.nih.gov/pubmed/32425546
http://dx.doi.org/10.2147/OTT.S245950
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