Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice

INTRODUCTION: Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of Alzheimer's disease (AD). However, the effectiveness of the drug is limited by its solubi...

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Detalles Bibliográficos
Autores principales: Kong, Liang, Li, Xue-tao, Ni, Ying-nan, Xiao, Hong-he, Yao, Ying-jia, Wang, Yuan-yuan, Ju, Rui-jun, Li, Hong-yan, Liu, Jing-jing, Fu, Min, Wu, Yu-tong, Yang, Jing-xian, Cheng, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186891/
https://www.ncbi.nlm.nih.gov/pubmed/32425521
http://dx.doi.org/10.2147/IJN.S239608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186891/
https://www.ncbi.nlm.nih.gov/pubmed/32425521
http://dx.doi.org/10.2147/IJN.S239608

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