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Functionalization of Piperidine Derivatives for the Site‐Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate

Rhodium‐catalyzed C−H insertions and cyclopropanations of donor/acceptor carbenes have been used for the synthesis of positional analogues of methylphenidate. The site selectivity is controlled by the catalyst and the amine protecting group. C−H functionalization of N‐Boc‐piperidine using Rh(2)(R‐TC...

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Detalles Bibliográficos
Autores principales: Liu, Wenbin, Babl, Tobias, Röther, Alexander, Reiser, Oliver, Davies, Huw M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187323/
https://www.ncbi.nlm.nih.gov/pubmed/31873946
http://dx.doi.org/10.1002/chem.201905773