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Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability

BACKGROUND: Walking independently is basic to human functioning. The Lifestyle Interventions and Independence for Elders (LIFE) studies were developed to assess whether initiating physical activity could prevent major mobility disability (MMD) in sedentary older adults. METHODS: We review the develo...

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Autores principales: Pahor, Marco, Guralnik, Jack M., Anton, Stephen D., Ambrosius, Walter T., Blair, Steven N., Church, Timothy S., Espeland, Mark A., Fielding, Roger A., Gill, Thomas M., Glynn, Nancy W., Groessl, Erik J., King, Abby C., Kritchevsky, Stephen B., Manini, Todd M., McDermott, Mary M., Miller, Michael E., Newman, Anne B., Williamson, Jeff D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187344/
https://www.ncbi.nlm.nih.gov/pubmed/32105353
http://dx.doi.org/10.1111/jgs.16365
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author Pahor, Marco
Guralnik, Jack M.
Anton, Stephen D.
Ambrosius, Walter T.
Blair, Steven N.
Church, Timothy S.
Espeland, Mark A.
Fielding, Roger A.
Gill, Thomas M.
Glynn, Nancy W.
Groessl, Erik J.
King, Abby C.
Kritchevsky, Stephen B.
Manini, Todd M.
McDermott, Mary M.
Miller, Michael E.
Newman, Anne B.
Williamson, Jeff D.
author_facet Pahor, Marco
Guralnik, Jack M.
Anton, Stephen D.
Ambrosius, Walter T.
Blair, Steven N.
Church, Timothy S.
Espeland, Mark A.
Fielding, Roger A.
Gill, Thomas M.
Glynn, Nancy W.
Groessl, Erik J.
King, Abby C.
Kritchevsky, Stephen B.
Manini, Todd M.
McDermott, Mary M.
Miller, Michael E.
Newman, Anne B.
Williamson, Jeff D.
author_sort Pahor, Marco
collection PubMed
description BACKGROUND: Walking independently is basic to human functioning. The Lifestyle Interventions and Independence for Elders (LIFE) studies were developed to assess whether initiating physical activity could prevent major mobility disability (MMD) in sedentary older adults. METHODS: We review the development and selected findings of the LIFE studies from 2000 through 2019, including the planning phase, the LIFE‐Pilot Study, and the LIFE Study. RESULTS: The planning phase and the LIFE‐Pilot provided key information for the successful implementation of the LIFE Study. The LIFE Study, involving 1635 participants randomized at eight sites throughout the United States, showed that compared with health education, the physical activity program reduced the risk of the primary outcome of MMD (inability to walk 400 m: hazard ratio = 0.82; 95% confidence interval = 0.69‐0.98; P = .03), and that the intervention was cost‐effective. There were no significant effects on cognitive outcomes, cardiovascular events, or serious fall injuries. In addition, the LIFE studies provided relevant findings on a broad range of other outcomes, including health, frailty, behavioral outcomes, biomarkers, and imaging. To date, the LIFE studies have generated a legacy of 109 peer‐reviewed publications, 19 ancillary studies, and 38 independently funded grants and clinical trials, and advanced the development of 59 early career scientists. Data and biological samples of the LIFE Study are now publicly available from a repository sponsored by the National Institute on Aging (https://urldefense.proofpoint.com/v2/url?u=https-3A__agingresearchbiobank.nia.nih.gov&d=DwMFAg&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=ZX4a6hcfLVk9tpCPmkSujQ&m=iTPARxl_LBOimJoAcWK4efKQBWBHszm-g4mUN_o5-bc&s=SrlCccrcYCFSyWnnprcB3rJXT3W3FkGkW0XmdJITNhE&e=). CONCLUSIONS: The LIFE studies generated a wealth of important scientific findings and accelerated research in geriatrics and gerontology, benefiting the research community, trainees, clinicians, policy makers, and the general public. J Am Geriatr Soc 68:872–881, 2020
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spelling pubmed-71873442020-04-28 Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability Pahor, Marco Guralnik, Jack M. Anton, Stephen D. Ambrosius, Walter T. Blair, Steven N. Church, Timothy S. Espeland, Mark A. Fielding, Roger A. Gill, Thomas M. Glynn, Nancy W. Groessl, Erik J. King, Abby C. Kritchevsky, Stephen B. Manini, Todd M. McDermott, Mary M. Miller, Michael E. Newman, Anne B. Williamson, Jeff D. J Am Geriatr Soc Review Articles BACKGROUND: Walking independently is basic to human functioning. The Lifestyle Interventions and Independence for Elders (LIFE) studies were developed to assess whether initiating physical activity could prevent major mobility disability (MMD) in sedentary older adults. METHODS: We review the development and selected findings of the LIFE studies from 2000 through 2019, including the planning phase, the LIFE‐Pilot Study, and the LIFE Study. RESULTS: The planning phase and the LIFE‐Pilot provided key information for the successful implementation of the LIFE Study. The LIFE Study, involving 1635 participants randomized at eight sites throughout the United States, showed that compared with health education, the physical activity program reduced the risk of the primary outcome of MMD (inability to walk 400 m: hazard ratio = 0.82; 95% confidence interval = 0.69‐0.98; P = .03), and that the intervention was cost‐effective. There were no significant effects on cognitive outcomes, cardiovascular events, or serious fall injuries. In addition, the LIFE studies provided relevant findings on a broad range of other outcomes, including health, frailty, behavioral outcomes, biomarkers, and imaging. To date, the LIFE studies have generated a legacy of 109 peer‐reviewed publications, 19 ancillary studies, and 38 independently funded grants and clinical trials, and advanced the development of 59 early career scientists. Data and biological samples of the LIFE Study are now publicly available from a repository sponsored by the National Institute on Aging (https://urldefense.proofpoint.com/v2/url?u=https-3A__agingresearchbiobank.nia.nih.gov&d=DwMFAg&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=ZX4a6hcfLVk9tpCPmkSujQ&m=iTPARxl_LBOimJoAcWK4efKQBWBHszm-g4mUN_o5-bc&s=SrlCccrcYCFSyWnnprcB3rJXT3W3FkGkW0XmdJITNhE&e=). CONCLUSIONS: The LIFE studies generated a wealth of important scientific findings and accelerated research in geriatrics and gerontology, benefiting the research community, trainees, clinicians, policy makers, and the general public. J Am Geriatr Soc 68:872–881, 2020 John Wiley & Sons, Inc. 2020-02-27 2020-04 /pmc/articles/PMC7187344/ /pubmed/32105353 http://dx.doi.org/10.1111/jgs.16365 Text en © 2020 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Pahor, Marco
Guralnik, Jack M.
Anton, Stephen D.
Ambrosius, Walter T.
Blair, Steven N.
Church, Timothy S.
Espeland, Mark A.
Fielding, Roger A.
Gill, Thomas M.
Glynn, Nancy W.
Groessl, Erik J.
King, Abby C.
Kritchevsky, Stephen B.
Manini, Todd M.
McDermott, Mary M.
Miller, Michael E.
Newman, Anne B.
Williamson, Jeff D.
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title_full Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title_fullStr Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title_full_unstemmed Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title_short Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
title_sort impact and lessons from the lifestyle interventions and independence for elders (life) clinical trials of physical activity to prevent mobility disability
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187344/
https://www.ncbi.nlm.nih.gov/pubmed/32105353
http://dx.doi.org/10.1111/jgs.16365
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