Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells

Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansi...

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Autores principales: Swatler, Julian, Dudka, Wioleta, Bugajski, Lukasz, Brewinska‐Olchowik, Marta, Kozlowska, Ewa, Piwocka, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187374/
https://www.ncbi.nlm.nih.gov/pubmed/31758697
http://dx.doi.org/10.1002/eji.201848051
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author Swatler, Julian
Dudka, Wioleta
Bugajski, Lukasz
Brewinska‐Olchowik, Marta
Kozlowska, Ewa
Piwocka, Katarzyna
author_facet Swatler, Julian
Dudka, Wioleta
Bugajski, Lukasz
Brewinska‐Olchowik, Marta
Kozlowska, Ewa
Piwocka, Katarzyna
author_sort Swatler, Julian
collection PubMed
description Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis. [Image: see text]
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spelling pubmed-71873742020-04-28 Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells Swatler, Julian Dudka, Wioleta Bugajski, Lukasz Brewinska‐Olchowik, Marta Kozlowska, Ewa Piwocka, Katarzyna Eur J Immunol Letter to the Editor Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis. [Image: see text] John Wiley and Sons Inc. 2019-12-05 2020-04 /pmc/articles/PMC7187374/ /pubmed/31758697 http://dx.doi.org/10.1002/eji.201848051 Text en © 2019 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Swatler, Julian
Dudka, Wioleta
Bugajski, Lukasz
Brewinska‐Olchowik, Marta
Kozlowska, Ewa
Piwocka, Katarzyna
Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title_full Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title_fullStr Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title_full_unstemmed Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title_short Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
title_sort chronic myeloid leukemia‐derived extracellular vesicles increase foxp3 level and suppressive activity of thymic regulatory t cells
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187374/
https://www.ncbi.nlm.nih.gov/pubmed/31758697
http://dx.doi.org/10.1002/eji.201848051
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