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Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells

Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansi...

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Detalles Bibliográficos
Autores principales:	Swatler, Julian, Dudka, Wioleta, Bugajski, Lukasz, Brewinska‐Olchowik, Marta, Kozlowska, Ewa, Piwocka, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187374/ https://www.ncbi.nlm.nih.gov/pubmed/31758697 http://dx.doi.org/10.1002/eji.201848051

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