REPIC: a database for exploring the N(6)-methyladenosine methylome

The REPIC (RNA EPItranscriptome Collection) database records about 10 million peaks called from publicly available m(6)A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users...

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Detalles Bibliográficos
Autores principales: Liu, Shun, Zhu, Allen, He, Chuan, Chen, Mengjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Database
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187508/
https://www.ncbi.nlm.nih.gov/pubmed/32345346
http://dx.doi.org/10.1186/s13059-020-02012-4
Descripción
Sumario:The REPIC (RNA EPItranscriptome Collection) database records about 10 million peaks called from publicly available m(6)A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users to query N(6)-methyladenosine (m(6)A) modification sites by specific cell lines or tissue types. In addition, it integrates m(6)A/MeRIP-seq data with 1418 histone ChIP-seq and 118 DNase-seq data tracks from the ENCODE project in a modern genome browser to present a comprehensive atlas of m(6)A methylation sites, histone modification sites, and chromatin accessibility regions. REPIC is accessible at https://repicmod.uchicago.edu/repic.

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